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Descriptor English: Gene Products, nef
Descriptor Spanish: Productos del Gen nef
Descriptor productos del gen nef
Entry term(s) proteína nef
Scope note: Productos del GEN NEF retrovírico. Actúan como proteínas accesorias que influyen en la tasa de infectividad vírica y la destrucción del sistema inmunitario del huésped. Los productos del gen nef se descubrieron por primera vez como factores supresores de la replicación vírica y funcionan como reguladores negativos de la transcripción. El término nef corresponde a "factor negativo".
Descriptor Portuguese: Produtos do Gene nef
Descriptor French: Produits du gène nef
Entry term(s): 3' orf Protein
3'-orf Protein
Gene Product, nef
nef Gene Product
nef Gene Products
nef Protein
Tree number(s): D12.776.964.775.362
D12.776.964.925.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015693
Scope note: Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Retroviridae Proteins (1987-1989)
Viral Proteins (1987-1988)
Public MeSH Note: 91; was see under VIRAL REGULATORY PROTEINS 1990
History Note: 91(90); was see under VIRAL REGULATORY PROTEINS 1990
DeCS ID: 24676
Unique ID: D015693
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1989/10/20
Revision Date: 2007/07/09
Gene Products, nef - Preferred
Concept UI M0024067
Scope note Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
Preferred term Gene Products, nef
Entry term(s) 3' orf Protein
3'-orf Protein
Gene Product, nef
nef Gene Product
nef Gene Products
nef Protein



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