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Descriptor English: Central Nervous System Agents
Descriptor Spanish: Fármacos del Sistema Nervioso Central
Descriptor fármacos del sistema nervioso central
Entry term(s) fármacos que actúan en el sistema nervioso central
Scope note: Clase de fármacos que producen efectos fisiológicos y psicológicos a través de diversos mecanismos. Pueden dividirse en fármacos específicos -- por ejemplo, los que afectan a un solo mecanismo molecular identificable para actuar en las células que poseen receptores de dicho fármaco -- y en fármacos inespecíficos, que son aquellos que producen efectos en diferentes tipos de células y que actúan mediante diversos mecanismos moleculares. Los que tienen mecanismos inespecíficos se clasifican generalmente según sus efectos de depresión o estimulación conductual. Los fármacos con mecanismos específicos se clasifican por el lugar de acción o por el uso terapéutico específico. (Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Descriptor Portuguese: Fármacos do Sistema Nervoso Central
Descriptor French: Agents du système nerveux central
Entry term(s): Central Nervous System Drugs
Tree number(s): D27.505.954.427
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002491
Scope note: A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Annotation: general or unspecified; prefer specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 79
Online Note: consider also CENTRAL NERVOUS SYSTEM /DE & BRAIN /DE
History Note: 79; was NON MESH before 1979
Entry Version: CNS AGENTS
DeCS ID: 2526
Unique ID: D002491
NLM Classification: QV 76.5
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1979/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/08/15
Central Nervous System Agents - Preferred
Concept UI M0003803
Scope note A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Preferred term Central Nervous System Agents
Entry term(s) Central Nervous System Drugs



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