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Descriptor English: Multigene Family
Descriptor Spanish: Familia de Multigenes
Descriptor familia multigénica
Entry term(s) agrupación génica
genes reiterados
grupo génico
Scope note: Grupo de genes que proceden de la duplicación y variación de un gen ancestral. Tales genes pueden estar agrupados en el mismo cromosoma o dispersos en diferentes cromosomas. Son ejemplos de familias de multigenes los genes que codifican las hemoglobinas, inmunoglobulina S, antígenos de histocompatibilidad, actinas, tubulinas, queratinas, colágenos, proteínas del choque térmico, proteínas salivales adhesivas, proteínas coriónicas, proteínas de las cutículas, proteínas del saco vitelino y faseolinas así como histonas, ARN ribosómico y ARN de transferencia. Los tres últimos son ejemplos de genes reiterados en los que están presentes cientos de genes idénticos organizados en tándem. (King & Stanfield, A Dictionary of Genetics, 4th ed).
Descriptor Portuguese: Família Multigênica
Descriptor French: Famille multigénique
Entry term(s): Cluster, Gene
Clusters, Gene
Families, Multigene
Family, Multigene
Gene Cluster
Gene Clusters
Gene, Reiterated
Genes, Reiterated
Multigene Families
Reiterated Gene
Reiterated Genes
Tree number(s): G05.360.340.024.340.645
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005810
Scope note: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Genes (1966-1970)
Genes, Bacterial (1982-1986)
Genes, Structural (1971-1986)
Genes, Viral (1978-1986)
Public MeSH Note: 97; was GENES, REITERATED 1987-96; MULTIGENE FAMILY was see GENES, REITERATED 1987-96
History Note: 97; was GENES, REITERATED 1987-96; MULTIGENE FAMILY was see GENES, REITERATED 1987-96
Related: Gene Duplication MeSH
Genes, Duplicate MeSH
Repetitive Sequences, Nucleic Acid MeSH
DeCS ID: 28070
Unique ID: D005810
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/19
Revision Date: 2008/07/08
Multigene Family - Preferred
Concept UI M0009111
Scope note A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Preferred term Multigene Family
Entry term(s) Families, Multigene
Family, Multigene
Multigene Families
Genes, Reiterated - Narrower
Concept UI M0009112
Preferred term Genes, Reiterated
Entry term(s) Gene, Reiterated
Reiterated Gene
Reiterated Genes
Gene Clusters - Narrower
Concept UI M0009110
Preferred term Gene Clusters
Entry term(s) Cluster, Gene
Clusters, Gene
Gene Cluster



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