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Descriptor in English: Genes, Lethal
Descriptor in Spanish: Genes Letales
Descriptor in Portuguese: Genes Letais
Descriptor in French: Gènes létaux
Entry term(s): Allele, Lethal
Alleles, Lethal
Gene, Lethal
Lethal Allele
Lethal Alleles
Lethal Gene
Lethal Genes
Tree number(s): G05.360.340.024.340.350
Scope note: Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
History Note: 68
See also the descriptors: Synthetic Lethal Mutations MeSH
DeCS UI: 5942
Descriptor UI: D005804
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/30
Genes, Lethal - Preferred
Concept UI M0009099
Scope note Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Preferred term Genes, Lethal
Entry term(s) Gene, Lethal
Lethal Gene
Lethal Genes
Alleles, Lethal - Narrower
Concept UI M0511448
Preferred term Alleles, Lethal
Entry term(s) Allele, Lethal
Lethal Allele
Lethal Alleles



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