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Descriptor English: Dizocilpine Maleate
Descriptor Spanish: Maleato de Dizocilpina
Descriptor maleato de dizocilpina
Entry term(s) MK-801
dizocilpina
Scope note: Potente antagonista no competitivo del receptor de NMDA (RECEPTORES DE N-METIL-D-ASPARTATO) utilizado principalmente como herramienta de investigación. Se ha considerado este fármaco para una amplia variedad de afecciones o trastornos neurodegenerativos en los que pueden desempeñar un papel importante los receptores de NMDA. Su empleo ha quedado limitado principalmente a experimentos tisulares por sus efectos psicotrópicos.
Descriptor Portuguese: Maleato de Dizocilpina
Descriptor French: Maléate de dizocilpine
Entry term(s): Dizocilpine
MK 801
MK-801
MK801
Tree number(s): D02.455.426.559.847.181.384.380
D04.615.181.384.380
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016291
Scope note: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Excitatory Amino Acid Antagonists
Neuroprotective Agents
Registry Number: 6LR8C1B66Q
CAS Type 1 Name: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)
Previous Indexing: Anticonvulsants (1966-1990)
Dibenzocycloheptenes (1968-1990)
Public MeSH Note: 91
History Note: 91
DeCS ID: 28911
Unique ID: D016291
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/05/25
Revision Date: 2013/07/08
Dizocilpine Maleate - Preferred
Concept UI M0024898
Scope note A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
Preferred term Dizocilpine Maleate
Dizocilpine - Narrower
Concept UI M0329461
Preferred term Dizocilpine
MK-801 - Narrower
Concept UI M0350546
Preferred term MK-801
Entry term(s) MK 801
MK801



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