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Descriptor English: Fibroblast Growth Factor 1
Descriptor Spanish: Factor 1 de Crecimiento de Fibroblastos
Descriptor factor 1 de crecimiento de fibroblastos
Entry term(s) HBGF-1
factor de crecimiento de fibroblastos de clase I de unión a heparina
factor de crecimiento de fibroblastos ácido
factor de crecimiento de unión a heparina de clase I
factor de crecimiento de unión a heparina, clase I
Scope note: Factor de crecimiento de una cadena polipeptídica de 17 kDa que desempeña un papel importante en el proceso de la CICATRIZACIÓN DE HERIDAS y es un potente inductor de la ANGIOGÉNESIS FISIOLÓGICA. Se une a la HEPARINA, que potencia su actividad biológica y la protege de la proteólisis. El factor de crecimiento es un inductor muy potente de la síntesis de ADN en una variedad de tipos celulares de los linajes mesodérmico y neuroectodérmico, y tiene también actividades quimiotácticas y mitogénicas. Fue denominado originalmente factor de crecimiento de fibroblastos ácido a tenor de sus propiedades químicas para distinguirla del factor de crecimiento de fibroblastos básico (FACTOR 2 DE CRECIMIENTO DE FIBROBLASTOS).
Descriptor Portuguese: Fator 1 de Crescimento de Fibroblastos
Descriptor French: Facteur de croissance fibroblastique de type 1
Entry term(s): Acidic Fibroblast Growth Factor
Class I Heparin-Binding Growth Factor
FGF-1
FGF1
Fibroblast Growth Factor, Acidic
Fibroblast Growth Factor-1
HBGF-1
Heparin Binding Growth Factor, Class I
Heparin-Binding Fibroblast Growth Factor Class I
Heparin-Binding Growth Factor, Class I
Tree number(s): D12.644.276.624.110
D12.776.467.624.110
D23.529.624.110
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016220
Scope note: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 104781-85-3
CAS Type 1 Name: Fibroblast growth factor (human brain acidic protein moiety reduced)
Previous Indexing: Fibroblast Growth Factor (1984-1990)
Growth Substances (1974-1983)
Public MeSH Note: 2002; FIBROBLAST GROWTH FACTOR-1 was indexed under FIBROBLAST GROWTH FACTOR ACIDIC 2001, FIBROBLAST GROWTH FACTOR 2000-2001 & under FIBROBLAST GROWTH FACTOR, BASIC 1998-2000
History Note: 2002(1991); for FIBROBLAST GROWTH FACTOR-1 use FIBROBLAST GROWTH FACTOR 1(NM) 1998-2001
DeCS ID: 28935
Unique ID: D016220
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/07/05
Revision Date: 2006/07/05
Fibroblast Growth Factor 1 - Preferred
Concept UI M0024768
Scope note A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Preferred term Fibroblast Growth Factor 1
Entry term(s) Acidic Fibroblast Growth Factor
Class I Heparin-Binding Growth Factor
FGF-1
FGF1
Fibroblast Growth Factor, Acidic
Fibroblast Growth Factor-1
HBGF-1
Heparin Binding Growth Factor, Class I
Heparin-Binding Fibroblast Growth Factor Class I
Heparin-Binding Growth Factor, Class I



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