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Descriptor English: Fibroblast Growth Factor 2
Descriptor Spanish: Factor 2 de Crecimiento de Fibroblastos
Descriptor factor 2 de crecimiento de fibroblastos
Entry term(s) HBGF-2
factor básico de crecimiento de fibroblastos
factor de crecimiento de fibroblastos básico
Scope note: Factor de crecimiento de una única cadena polipeptídica que desempeña un papel importante en el proceso de la CICATRIZACIÓN DE HERIDAS y es un potente inductor de la ANGIOGÉNESIS FISIOLÓGICA. Hay varias formas diferentes de la proteína humana, con un tamaño que va de 18 a 24 kDa debido al empleo de sitios de comienzo alternativos dentro del gen fgf-2. Tiene una identidad de residuos aminoácidos del 55 por ciento con el FACTOR 1 DE CRECIMIENTO DE FIBROBLASTOS y una potente actividad de unión a heparina. El factor de crecimiento es un inductor extraordinariamente potente de la síntesis de ADN en una variedad de tipos celulares de linaje mesodérmico y neuroectodérmico. Fue denominado originalmente factor de crecimiento de fibroblastos básico por sus propiedades químicas y para distinguirlo del factor de crecimiento de fibroblastos ácido (FACTOR 1 DE CRECIMIENTO DE FIBROBLASTOS).
Descriptor Portuguese: Fator 2 de Crescimento de Fibroblastos
Descriptor French: Facteur de croissance fibroblastique de type 2
Entry term(s): Basic Fibroblast Growth Factor
Cartilage Derived Growth Factor
Cartilage-Derived Growth Factor
Class II Heparin-Binding Growth Factor
FGF 2
FGF-2
FGF2
Fibroblast Growth Factor, Basic
Fibroblast Growth Factor-2
HBGF-2
Heparin-Binding Growth Factor Class II
Prostate Epithelial Cell Growth Factor
Prostatropin
Tree number(s): D12.644.276.624.120
D12.776.467.624.120
D23.529.624.120
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016222
Scope note: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 103107-01-3
Previous Indexing: Fibroblast Growth Factor (1984-1990)
Growth Substances (1974-1983)
Public MeSH Note: 2001; FIBROBLAST GROWTH FACTOR-2 was indexed under FIBROBLAST GROWTH FACTOR, BASIC 1996-2001 & under FIBROBLAST GROWTH FACTOR 1995; PROSTATROPIN was indexed under NERVE TISSUE PROTEINS 1986-2001; CARTILAGE-DERIVED GROWTH FACTOR was indexed under PROTEINS 2005-2006
History Note: 2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001
DeCS ID: 28936
Unique ID: D016222
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/28
Revision Date: 2013/07/09
Fibroblast Growth Factor 2 - Preferred
Concept UI M0024770
Scope note A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Preferred term Fibroblast Growth Factor 2
Entry term(s) Basic Fibroblast Growth Factor
Cartilage Derived Growth Factor
Cartilage-Derived Growth Factor
Class II Heparin-Binding Growth Factor
FGF 2
FGF-2
FGF2
Fibroblast Growth Factor, Basic
Fibroblast Growth Factor-2
HBGF-2
Heparin-Binding Growth Factor Class II
Prostate Epithelial Cell Growth Factor
Prostatropin



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