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Descriptor English: Granulocyte Colony-Stimulating Factor
Descriptor Spanish: Factor Estimulante de Colonias de Granulocitos
Descriptor factor estimulador de colonias de granulocitos
Entry term(s) G-CSF
factor de crecimiento mieloide
factor estimulante de colonias de granulocitos
Scope note: Glicoproteína de PM 25 kDa que contiene enlaces disulfuro internos. Induce la supervivencia, proliferación y diferenciación de las células precursoras de los granulocitos neutrófilos y funcionalmente activa los neutrófilos maduros de la sangre. Entre la familia de los factores que estimulan las colonias, el G-CSF es el inductor más potente de la diferenciación terminal a granulocitos y macrófagos de las líneas celulares de la leucemia mieloide.
Descriptor Portuguese: Fator Estimulador de Colônias de Granulócitos
Descriptor French: Facteur de stimulation des colonies de granulocytes
Entry term(s): Colony-Stimulating Factor, Granulocyte
G-CSF
Myeloid Growth Factor
Tree number(s): D09.400.430.775.200
D12.644.276.374.410.240.350
D12.776.395.240.200
D12.776.467.374.410.240.350
D23.529.374.410.240.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016179
Scope note: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 143011-72-7
CAS Type 1 Name: Colony-stimulating factor, granulocyte
Previous Indexing: Colony-Stimulating Factors (1976-1990)
Public MeSH Note: 91
History Note: 91
Entry Version: GCSF
Related: Receptors, Granulocyte Colony-Stimulating Factor MeSH
DeCS ID: 28968
Unique ID: D016179
NLM Classification: WH 200
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2011/06/24
Granulocyte Colony-Stimulating Factor - Preferred
Concept UI M0024696
Scope note A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Preferred term Granulocyte Colony-Stimulating Factor
Entry term(s) Colony-Stimulating Factor, Granulocyte
G-CSF
Myeloid Growth Factor



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