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Qualifier English: Sp1 Transcription Factor
Qualifier Spanish: Factor de Transcripción Sp1
Descriptor factor de transcripción Sp1
Scope note: Factor de transcripción promotor de la polimerasa II específica del ARN, que se une a la "GC box", uno de los elementos PROMOTOR (GENÉTICA) en las células de mamíferos. El enlace del Sp1 es necesario para iniciar la transcripción en los promotores de distintos GENES celulares y virales.
Qualifier Portuguese: Fator de Transcrição Sp1
Qualifier French: Facteur de transcription Sp1
Entry term(s): Specificity Protein 1 Transcription Factor
Transcription Factor, Sp1
Tree number(s): D12.776.260.522.750.249
D12.776.930.375.750.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016329
Scope note: Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Annotation: /drug eff /ultrastruct permitted; in titles & translations use SP1 (the figure one), not SPl (the letter l)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA-Binding Proteins (1986-1990)
Transcription Factors (1986-1990)
Public MeSH Note: 2006; see TRANSCRIPTION FACTOR, SP1 1991-2005
History Note: 2006(1991)
DeCS ID: 29137
Unique ID: D016329
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2009/07/14
Sp1 Transcription Factor - Preferred
Concept UI M0024957
Scope note Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Preferred term Sp1 Transcription Factor
Entry term(s) Specificity Protein 1 Transcription Factor
Transcription Factor, Sp1



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