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Descriptor English: Sp7 Transcription Factor
Descriptor Spanish: Factor de Transcripción Sp7
Descriptor factor de transcripción Sp7
Entry term(s) proteína Osterix
Scope note: Factor de transcripción Sp que contiene tres DEDOS DE ZINC CYS2-HIS2. Se une a SECUENCIAS RICAS EN GC y desempeña una función esencial en la regulación de la expresión génica para la diferenciación de los OSTEOBLASTOS. Las mutaciones en el gen SP7 se asocian a la OSTEOGÉNESIS IMPERFECTA de tipo 12.
Descriptor Portuguese: Fator de Transcrição Sp7
Descriptor French: Facteur de transcription Sp7
Entry term(s): Osterix Protein
Transcription Factor, Sp7
Tree number(s): D12.776.260.522.750.937
D12.776.930.375.750.937
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076182
Scope note: An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Transcription Factors (2003-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57116
Unique ID: D000076182
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Sp7 Transcription Factor - Preferred
Concept UI M000632417
Scope note An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.
Preferred term Sp7 Transcription Factor
Entry term(s) Osterix Protein
Transcription Factor, Sp7



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