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Descriptor English: Talin
Descriptor Spanish: Talina
Descriptor talina
Scope note: Proteína citoplasmática de 235-kDa que se encuentra también en las plaquetas. Se ha localizado en regiones de adhesión del sustrato celular. Se une a las INTEGRINAS, VINCULINA y ACTINAS, y parece participar en la generación de una conexión transmembrana entre la matriz extracelular y el citoesqueleto.
Descriptor Portuguese: Talina
Descriptor French: Taline
Entry term(s): Band 2 Protein
Platelet Protein p235
Protein p235, Platelet
Protein, Band 2
Tree number(s): D12.776.220.985
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016608
Scope note: A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
Annotation: a cytoplasmic protein; /drug eff /ultrastruct permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Blood Proteins (1984-1986)
Contractile Proteins (1982-1986)
Cytoskeletal Proteins (1985-1991)
Muscle Proteins (1984-1986)
Public MeSH Note: 92; TALIN was indexed under CYTOSKELETAL PROTEINS 1987-91, under MUSCLE PROTEINS 1984-86 & under CONTRACTILE PROTEINS 1982-86
Online Note: use TALIN (NM) to search TALIN 1977-91
History Note: 92; was TALIN (NM) 1984-91
DeCS ID: 29792
Unique ID: D016608
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2001/07/25
Talin - Preferred
Concept UI M0025326
Scope note A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
Preferred term Talin
Entry term(s) Band 2 Protein
Protein, Band 2
Platelet Protein p235 - Narrower
Concept UI M0025327
Preferred term Platelet Protein p235
Entry term(s) Protein p235, Platelet



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