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Descriptor in English: Neurofibrillary Tangles
Descriptor in Spanish: Ovillos Neurofibrilares
Descriptor in Portuguese: Emaranhados Neurofibrilares
Descriptor in French: Enchevêtrements neurofibrillaires
Entry term(s): Neurofibrillary Tangle
Tangle, Neurofibrillary
Tangles, Neurofibrillary
Tree number(s): A08.675.609.520
A11.284.430.214.190.750.640.520
A11.671.573.520
Scope note: Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
Allowable Qualifiers: CH chemistry
CL classification
DE drug effects
EN enzymology
GE genetics
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
History Note: 92
See also the descriptors: Diffuse Neurofibrillary Tangles with Calcification MeSH
Neurofibrils MeSH
Neurofilament Proteins MeSH
Tauopathies MeSH
DeCS UI: 29933
Descriptor UI: D016874
Date Established: 1992/01/01
Date of Entry: 1991/05/02
Revision Date: 2014/06/13
Neurofibrillary Tangles - Preferred
Concept UI M0025677
Scope note Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
Preferred term Neurofibrillary Tangles
Entry term(s) Neurofibrillary Tangle
Tangle, Neurofibrillary
Tangles, Neurofibrillary



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