Search
Descriptor English: Interferon-alpha
Descriptor Spanish: Interferón-alfa
Descriptor interferón alfa
Entry term(s) alfa-interferón
Scope note: Es uno de los interferones de tipo I producidos por los leucocitos o células linfoblastoides de sangre periférica. Además de tener actividad antivírica, activa las CÉLULAS ASESINAS NATURALES y los LINFOCITOS B, además de inhibir la expresión del FACTOR DE CRECIMIENTO DEL ENDOTELIO VASCULAR por las vías de señalización de la PI-A3 CINASA y CINASAS MAPK.
Descriptor Portuguese: Interferon-alfa
Descriptor French: Interféron alpha
Entry term(s): IFN alpha D
IFN alpha5
IFN-alpha D
IFN-alpha5
Interferon Alfa
Interferon alpha
Interferon alpha 1
Interferon alpha 17
Interferon alpha 4
Interferon alpha 5
Interferon alpha 7
Interferon alpha 88
Interferon alpha J
Interferon alpha T
Interferon alpha-1
Interferon alpha-17
Interferon alpha-4
Interferon alpha-5
Interferon alpha-7
Interferon alpha-88
Interferon alpha-J
Interferon alpha-T
Interferon alpha4
Interferon alpha5
Interferon, Leukocyte
Interferon, Lymphoblast
Interferon, Lymphoblastoid
Interferon, alpha
LeIF I
LeIF J
Leif D
Leukocyte Interferon
Lymphoblast Interferon
Lymphoblastoid Interferon
alpha Interferon
alpha-Interferon
Tree number(s): D12.644.276.374.440.890.250
D12.776.467.374.440.890.250
D23.529.374.440.890.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016898
Scope note: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Antiviral Agents
Immunologic Factors
Previous Indexing: Interferon Type I (1983-1991)
Public MeSH Note: 1992; see INTERFERON TYPE I 1983-1991, INTERFERON ALPHA-1 was indexed under INTERFERON-ALPHA 2001-2011, INTERFERON-ALPHA 2 was indexed under INTERFERON-ALPHA 1997-2011, INTERFERON ALPHA4 was indexed under INTERFERON-ALPHA 1993-2001, INTERFERON ALPHA5 was indexed under INTERFERON-ALPHA 1996-2001
History Note: 1992; for INTERFERON, LYMPHOBLAST and INTERFERON, LEUKOCYTE use INTERFERON TYPE I 1989-1991
DeCS ID: 30033
Unique ID: D016898
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2018/01/11
Interferon-alpha - Preferred
Concept UI M0025711
Scope note One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Preferred term Interferon-alpha
Entry term(s) Interferon Alfa
Interferon alpha
Interferon, Leukocyte
Interferon, Lymphoblast
Interferon, Lymphoblastoid
Interferon, alpha
Leukocyte Interferon
Lymphoblast Interferon
Lymphoblastoid Interferon
alpha Interferon
alpha-Interferon
Interferon alpha-17 - Narrower
Concept UI M0552551
Preferred term Interferon alpha-17
Entry term(s) Interferon alpha 17
Interferon alpha 88
Interferon alpha T
Interferon alpha-88
Interferon alpha-T
LeIF I
Interferon alpha-5 - Narrower
Concept UI M0264080
Preferred term Interferon alpha-5
Entry term(s) IFN alpha5
IFN-alpha5
Interferon alpha 5
Interferon alpha5
Interferon alpha-7 - Narrower
Concept UI M0552552
Preferred term Interferon alpha-7
Entry term(s) Interferon alpha 7
Interferon alpha J
Interferon alpha-J
LeIF J
Interferon alpha-1 - Narrower
Concept UI M0402785
Preferred term Interferon alpha-1
Entry term(s) IFN alpha D
IFN-alpha D
Interferon alpha 1
Leif D
Interferon alpha-4 - Narrower
Concept UI M0220955
Preferred term Interferon alpha-4
Entry term(s) Interferon alpha 4
Interferon alpha4



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey