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Descriptor English: Clomipramine
Descriptor Spanish: Clomipramina
Descriptor clomipramina
Entry term(s) clorimipramina
Scope note: Antidepresivo tricíclico similar a la IMIPRAMINA, que inhibe selectivamente la captación de serotonina en el encéfalo. Se absorbe fácilmente en el tracto gastrointestinal y, en el hígado, sufre una desmetilación para formar su principal metabolito activo, la desmetilclomipramina.
Descriptor Portuguese: Clomipramina
Descriptor French: Clomipramine
Entry term(s): Anafranil
Chlomipramine
Chlorimipramine
Clomipramine Hydrochloride
Clomipramine Maleate (1:1)
Clomipramine Monohydrochloride
Hydiphen
Hydrochloride, Clomipramine
Monohydrochloride, Clomipramine
Tree number(s): D03.633.300.240.194
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002997
Scope note: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antidepressive Agents, Tricyclic
Serotonin Uptake Inhibitors
Registry Number: NUV44L116D
CAS Type 1 Name: 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-
Previous Indexing: Dibenzazepines (1968-1974)
Public MeSH Note: 80; was CHLORIMIPRAMINE see under DIBENZAZEPINES 1968-79
Online Note: use CLOMIPRAMINE to search CHLORIMIPRAMINE 1975-79; use DIBENZAZEPINES 1968-74
History Note: 80(75); was CHLORIMIPRAMINE see under DIBENZAZEPINES 1968-79
DeCS ID: 3022
Unique ID: D002997
NLM Classification: QV 77.5
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Clomipramine - Preferred
Concept UI M0004598
Scope note A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Preferred term Clomipramine
Entry term(s) Chlomipramine
Chlorimipramine
Hydiphen - Narrower
Concept UI M0004599
Preferred term Hydiphen
Clomipramine Maleate (1:1) - Narrower
Concept UI M0330564
Preferred term Clomipramine Maleate (1:1)
Clomipramine Monohydrochloride - Narrower
Concept UI M0330566
Preferred term Clomipramine Monohydrochloride
Entry term(s) Monohydrochloride, Clomipramine
Anafranil - Related but not broader or narrower
Concept UI M0004597
Preferred term Anafranil
Clomipramine Hydrochloride - Narrower
Concept UI M0004600
Preferred term Clomipramine Hydrochloride
Entry term(s) Hydrochloride, Clomipramine



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