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Descriptor English: Apolipoprotein A-I
Descriptor Spanish: Apolipoproteína A-I
Descriptor apolipoproteína A-I
Entry term(s) Apo A-I
Scope note: El componente proteico más abundante de las LIPOPROTEÍNAS DE ALTA DENSIDAD o HDL. Esta proteína sirve como aceptor de COLESTEROL liberado de las células, promoviendo así la salida de colesterol al HDL y luego al HÍGADO para su excreción del cuerpo (transporte de colesterol inverso). Actúa también como cofactor para la LECITINA COLESTEROL ACILTRANSFERASA que forma ÉSTERES DE COLESTEROL en las partículas HDL. Las mutaciones de este gen APOA1 causan deficiencia en HDL, como en la ENFERMEDAD FAMILIAR POR DEFICIENCIA EN LIPOPROTEÍNA ALFA y en algunos pacientes con ENFERMEDAD DE TANGIER.
Descriptor Portuguese: Apolipoproteína A-I
Descriptor French: Apolipoprotéine A-I
Entry term(s): Apo A I Isoproteins
Apo A-1
Apo A-I
Apo A-I Isoproteins
Apo A1
Apo AI
ApoA-1
ApoA-I
Apolipoprotein A 1
Apolipoprotein A I
Apolipoprotein A I Isoprotein 2
Apolipoprotein A I Isoprotein 4
Apolipoprotein A I Isoproteins
Apolipoprotein A-1
Apolipoprotein A-I Isoprotein-2
Apolipoprotein A-I Isoprotein-4
Apolipoprotein A-I Isoproteins
Apolipoprotein A1
Apolipoprotein AI
Apolipoprotein AI Propeptide
Pro Apo A I
Pro Apolipoprotein A I
Pro-Apo A-I
Pro-Apolipoprotein A-I
Proapolipoprotein AI
Tree number(s): D10.532.091.200.100
D12.776.070.400.200.100
D12.776.521.120.200.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016632
Scope note: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Apolipoproteins (1977-1984)
Apolipoproteins A (1985-1991)
Public MeSH Note: 1992; APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A 1985-1991, under APOLIPOPROTEINS 1979-1984 & under APOPROTEINS 1974-1978; PRO-APOLIPOPROTEIN A-I was indexed under APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; APOLIPOPROTEIN A-I ISOPROTEINS was indexed under APOLIPOPROTEINS A 1980-2006
History Note: 1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006
DeCS ID: 30252
Unique ID: D016632
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/24
Revision Date: 2006/07/05
Apolipoprotein A-I - Preferred
Concept UI M0025348
Scope note The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Preferred term Apolipoprotein A-I
Entry term(s) Apo A-1
Apo A-I
Apo A1
Apo AI
ApoA-1
ApoA-I
Apolipoprotein A 1
Apolipoprotein A I
Apolipoprotein A-1
Apolipoprotein A1
Apolipoprotein AI
Pro-Apolipoprotein A-I - Narrower
Concept UI M0117573
Preferred term Pro-Apolipoprotein A-I
Entry term(s) Apolipoprotein AI Propeptide
Pro Apo A I
Pro Apolipoprotein A I
Pro-Apo A-I
Proapolipoprotein AI
Apolipoprotein A-I Isoproteins - Narrower
Concept UI M0087284
Scope note Variants of apolipoprotein A-I. They include secreted propeptide form (isoprotein 2), the converted plasma form (isoprotein-4), and those with various substitutions or deletions.
Preferred term Apolipoprotein A-I Isoproteins
Entry term(s) Apo A I Isoproteins
Apo A-I Isoproteins
Apolipoprotein A I Isoproteins
Apolipoprotein A-I Isoprotein-2 - Narrower
Concept UI M0087282
Preferred term Apolipoprotein A-I Isoprotein-2
Entry term(s) Apolipoprotein A I Isoprotein 2
Apolipoprotein A-I Isoprotein-4 - Narrower
Concept UI M0087283
Preferred term Apolipoprotein A-I Isoprotein-4
Entry term(s) Apolipoprotein A I Isoprotein 4



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