Descriptor English: | Clozapine |
Descriptor Spanish: | Clozapina |
Descriptor Portuguese: | Clozapina |
Descriptor French: | Clozapine |
Entry term(s): |
Clozaril Leponex |
Tree number(s): |
D03.633.300.240.220 |
RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D003024 |
Scope note: | A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
Pharm Action: |
Serotonin Antagonists Antipsychotic Agents GABA Antagonists |
Registry Number: | J60AR2IKIC |
CAS Type 1 Name: | 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- |
Previous Indexing: |
Dibenzazepines (1971-1974) Piperazines (1971-1974) |
Public MeSH Note: | 91; was see under DIBENZAZEPINES 1975-90 |
History Note: | 91(75); was see under DIBENZAZEPINES 1975-90 |
DeCS ID: | 3051 |
Unique ID: | D003024 |
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents |
Date Established: | 1991/01/01 |
Date of Entry: | 1974/11/19 |
Revision Date: | 2016/05/28 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
|
Clozapine
- Preferred
Clozaril
- Narrower
Leponex
- Narrower
Concept UI |
M0004649 |
Scope note | A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. |
Preferred term | Clozapine |
Concept UI |
M0354010 |
Preferred term | Clozaril |
Concept UI |
M0354009 |
Preferred term | Leponex |
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