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Descriptor English: Clozapine
Descriptor Spanish: Clozapina
Descriptor Portuguese: Clozapina
Descriptor French: Clozapine
Entry term(s): Clozaril
Leponex
Tree number(s): D03.633.300.240.220
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003024
Scope note: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Serotonin Antagonists
Antipsychotic Agents
GABA Antagonists
Registry Number: J60AR2IKIC
CAS Type 1 Name: 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Previous Indexing: Dibenzazepines (1971-1974)
Piperazines (1971-1974)
Public MeSH Note: 91; was see under DIBENZAZEPINES 1975-90
History Note: 91(75); was see under DIBENZAZEPINES 1975-90
DeCS ID: 3051
Unique ID: D003024
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/28
Clozapine - Preferred
Concept UI M0004649
Scope note A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Preferred term Clozapine
Clozaril - Narrower
Concept UI M0354010
Preferred term Clozaril
Leponex - Narrower
Concept UI M0354009
Preferred term Leponex



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