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Descriptor English: Clozapine
Descriptor Spanish: Clozapina
Descriptor clozapina
Scope note: Dibenzodiacepina tricíclica, clasificada como agente antipsicótico atípico. Se une a diversos tipos de receptores del sistema nervioso central y muestra un único perfil farmacológico. La clozapina es un antagonista de la serotonina, a la que se une fuertemente en los subtipos de receptores 5-HT 2A-2C. También muestra una marcada afinidad por algunos receptores dopaminérgicos, si bien muestra un débil antagonismo con el receptor D2 de dopamina, un receptor que se cree que modula la actividad neuroléptica. El principal efecto adverso asociado con la administracion de este agente es la agranulocitosis.
Descriptor Portuguese: Clozapina
Descriptor French: Clozapine
Entry term(s): Clozaril
Leponex
Tree number(s): D03.633.300.240.220
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003024
Scope note: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Serotonin Antagonists
Antipsychotic Agents
GABA Antagonists
Registry Number: J60AR2IKIC
CAS Type 1 Name: 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
Previous Indexing: Dibenzazepines (1971-1974)
Piperazines (1971-1974)
Public MeSH Note: 91; was see under DIBENZAZEPINES 1975-90
History Note: 91(75); was see under DIBENZAZEPINES 1975-90
DeCS ID: 3051
Unique ID: D003024
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/28
Clozapine - Preferred
Concept UI M0004649
Scope note A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Preferred term Clozapine
Clozaril - Narrower
Concept UI M0354010
Preferred term Clozaril
Leponex - Narrower
Concept UI M0354009
Preferred term Leponex



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