DeCS

Descriptor English:

Clarithromycin

Descriptor Spanish:

Claritromicina

Spanish from Spain

Descriptor	claritromicina
Scope note:	Antibiótico macrólido semisintético derivado de la ERITROMICINA, activo frente diversos microorganismos. Inhibe la SÍNTESIS PROTEICA en las BACTERIAS al unirse reversiblemente a las subunidades ribosómicas 50S. Así se inhibe la translocación del aminoacil ARN de transferencia y se previene la elongación de la cadena peptídica.

Descriptor Portuguese:

Claritromicina

Descriptor French:

Clarithromycine

Entry term(s):

A-56268
A56268
TE-031
TE031

Tree number(s):

D02.540.576.500.992.100

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D017291

Scope note:

A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Bacterial Agents
Protein Synthesis Inhibitors
Cytochrome P-450 CYP3A Inhibitors

Registry Number:

H1250JIK0A

CAS Type 1 Name:

Erythromycin, 6-O-methyl-

DeCS ID:

30785

Unique ID:

D017291

Documents indexed in the Virtual Health Library (VHL):

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