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Descriptor English: Leukocyte Common Antigens
Descriptor Spanish: Antígenos Comunes de Leucocito
Descriptor antígenos comunes de los leucocitos
Entry term(s) antígeno B220
antígeno común de leucocito
antígenos 2H4
antígenos B220
antígenos CD45
antígenos CD45R
antígenos CD45RA
antígenos CD45RB
antígenos CD45RC
antígenos CD45RO
antígenos L-CA
antígenos T200
receptores de la proteína tirosina fosfatasa tipo C
Scope note: Glucoproteínas de alto peso molecular que se expresan exclusivamente en la superficie de los LEUCOCITOS y de sus progenitores hematopoyéticos. Contienen dos DOMINIOS DE FIBRONECTINA TIPO III y poseen actividad tirosina fosfatasa en el citoplasma, que desempeña un papel en la señalización intracelular a partir de los RECEPTORES DE SUPERFICIE CELULAR. Los antígenos CD45 tienen múltiples isoformas, resultantes de un corte y empalme alternativo del ARNm y del uso diferencial de tres exones.
Descriptor Portuguese: Antígenos Comuns de Leucócito
Descriptor French: Antigènes CD45
Entry term(s): 2H4 Antigens
Antigen, B220
Antigen, CD45
Antigen, Leukocyte Common
Antigens, 2H4
Antigens, B220
Antigens, CD45
Antigens, CD45R
Antigens, CD45R0
Antigens, CD45RA
Antigens, CD45RB
Antigens, CD45RO
Antigens, L-CA
Antigens, Leukocyte Common
Antigens, T200
B220 Antigen
B220 Antigens
CD45 Antigen
CD45 Antigens
CD45R Antigens
CD45R0 Antigens
CD45RA Antigens
CD45RB Antigens
CD45RCAntigens
CD45RO Antigens
L CA Antigens
L-CA Antigens
Leukocyte Common Antigen
Protein Tyrosine Phosphatase, Receptor Type, C
T200 Antigens
Tree number(s): D08.811.277.352.650.775.400.100.500
D12.776.476.564.400.100.500
D12.776.543.733.937.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017493
Scope note: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.3.48
Previous Indexing: Antigens, CD (1989-1992)
Antigens, Differentiation (1984-1991)
Histocompatibility Antigens (1984-1992)
Public MeSH Note: 2018; see ANTIGENS, CD45 1993-2017 and CD45 ANTIGEN 1984-1992; CD45 ANTIGEN was indexed under ANTIGENS, CD 1989-92 and HISTOCOMPATIBILITY ANTIGENS & ANTIGENS, DIFFERENTIATION 1984-92; RT7 ANTIGEN was indexed under HISTOCOMPATIBILITY ANTIGENS 1983-92; B220 ANTIGEN was indexed under ANTIGENS, SURFACE 1990-95
History Note: 2018 (1993); for RT7 use HISTOCOMPATIBILITY ANTIGENS RT 1983-92; for B220 ANTIGEN use ANTIGENS, CD45 1990-95
DeCS ID: 30830
Unique ID: D017493
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/13
Revision Date: 2017/05/24
Leukocyte Common Antigens - Preferred
Concept UI M0026536
Scope note High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Preferred term Leukocyte Common Antigens
Entry term(s) Antigen, CD45
Antigen, Leukocyte Common
Antigens, CD45
Antigens, L-CA
Antigens, Leukocyte Common
Antigens, T200
CD45 Antigen
CD45 Antigens
L CA Antigens
L-CA Antigens
Leukocyte Common Antigen
Protein Tyrosine Phosphatase, Receptor Type, C
T200 Antigens
CD45RO Antigens - Related but not broader or narrower
Concept UI M0026542
Scope note A low molecular weight isoform of CD45 antigen.
Preferred term CD45RO Antigens
Entry term(s) Antigens, CD45R0
Antigens, CD45RO
CD45R0 Antigens
CD45RB Antigens - Narrower
Concept UI M0026541
Scope note A splicing isoform of CD45 antigen that includes exon B.
Preferred term CD45RB Antigens
Entry term(s) Antigens, CD45RB
CD45RCAntigens - Narrower
Concept UI M0026544
Scope note A splicing isoform of CD45 antigen that includes exon C.
Preferred term CD45RCAntigens
B220 Antigens - Narrower
Concept UI M0026537
Scope note A full-length splicing isoform of CD45 antigen.
Preferred term B220 Antigens
Entry term(s) Antigen, B220
Antigens, B220
Antigens, CD45R
B220 Antigen
CD45R Antigens
CD45RA Antigens - Narrower
Concept UI M0026540
Scope note A splicing isoform of CD45 antigen that includes exon A.
Preferred term CD45RA Antigens
Entry term(s) 2H4 Antigens
Antigens, 2H4
Antigens, CD45RA



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