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Descriptor English: Plicamycin
Descriptor Spanish: Plicamicina
Descriptor plicamicina
Entry term(s) mitramicina
ácido aureólico
Scope note: Antibiótico tricíclico pentaglicosídico de cepas de Streptomyces que inhibe la síntesis de ARN y de proteínas al adheririse al ARN. Se emplea como colorante fluorescente y agente antineoplásico, especialmente en tumores óseos y testiculares. También se emplea la plicamicina para reducir la hipercalcemia, especialmente la debida a enfermedades malignas.
Descriptor Portuguese: Plicamicina
Descriptor French: Mithramycine
Entry term(s): Aureolic Acid
Mithramycin
Mitramycin
Tree number(s): D02.455.426.559.847.562.050.650
D04.615.562.050.650
D09.408.051.059.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008926
Scope note: A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Calcium-Regulating Hormones and Agents
Antibiotics, Antineoplastic
Fluorescent Dyes
Protein Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
Registry Number: NIJ123W41V
CAS Type 1 Name: Mithramycin
Previous Indexing: Antibiotics, Antineoplastic (1967-1970)
Public MeSH Note: 93; was MITHRAMYCIN 1973-92
Online Note: use PLICAMYCIN to search MITHRAMYCIN 1971-92 (as Prov 1971-72)
History Note: 93; was MITHRAMYCIN 1971-92 (Prov 1971-72)
DeCS ID: 30896
Unique ID: D008926
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/22
Plicamycin - Preferred
Concept UI M0013935
Scope note A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Preferred term Plicamycin
Entry term(s) Aureolic Acid
Mithramycin
Mitramycin



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