| Descriptor English: | Plicamycin | ||||||
| Descriptor Spanish: |
Plicamicina
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| Descriptor Portuguese: | Plicamicina | ||||||
| Descriptor French: | Mithramycine | ||||||
| Entry term(s): |
Aureolic Acid Mithramycin Mitramycin |
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| Tree number(s): |
D02.455.426.559.847.562.050.650 D04.615.562.050.650 D09.408.051.059.650 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D008926 | ||||||
| Scope note: | A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Calcium-Regulating Hormones and Agents Antibiotics, Antineoplastic Fluorescent Dyes Protein Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors |
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| Registry Number: | NIJ123W41V | ||||||
| CAS Type 1 Name: | Mithramycin | ||||||
| Previous Indexing: |
Antibiotics, Antineoplastic (1967-1970) |
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| Public MeSH Note: | 93; was MITHRAMYCIN 1973-92 |
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| Online Note: | use PLICAMYCIN to search MITHRAMYCIN 1971-92 (as Prov 1971-72) |
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| History Note: | 93; was MITHRAMYCIN 1971-92 (Prov 1971-72) |
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| DeCS ID: | 30896 | ||||||
| Unique ID: | D008926 | ||||||
| NLM Classification: | QV 269 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1973/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2018/05/22 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds -
CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates
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Plicamycin
- Preferred
| Concept UI |
M0013935 |
| Scope note | A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies. |
| Preferred term | Plicamycin |
| Entry term(s) |
Aureolic Acid Mithramycin Mitramycin |
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