DeCS

Descriptor English:

Pradimicins and Benanomicins

Descriptor Spanish:

Pradimicinas y Benanomicinas

Spanish from Spain

Descriptor	pradimicinas y benanomicinas
Entry term(s)	antibióticos benanomicínicos antibióticos benanomicínicos y pradimicínicos antibióticos pradimicínicos antibióticos pradimicínicos y benanomicínicos benanomicinas benanomicinas y pradimicinas benanomicinonas policétidos similares a la pradimicina polifenoles de tipo pradimicina pradimicinas pradimicinonas
Scope note:	Policétidos aromáticos policíclicos con esqueletos pentacíclicos angulares de dihidrobenzo(a)naftacenoquinona. Los polifenoles de tipo pramidicina y de tipo benanomicina relacionados son producidos por actinobacterias, como ACTINOMADURA, por medio de la policétido-sintasa de tipo II con condensación de una molécula de acetil-CoA y nueve moléculas de malonil-CoA. Las pradimicinas y las benanomicinas tienen un aminoácido (p. ej., D-ALANINA) y a menudo un 5-O-azúcar y se unen a D-manósidos terminales de la pared celular de diversos hongos, como CANDIDA. Además de actividad antifúngica, muchas pradimicinas y benanomicinas tienen actividad anti-VIH.

Descriptor Portuguese:

Pradimicinas e Benanomicinas

Descriptor French:

Without translation

Entry term(s):

Benanomicin Antibiotics
Benanomicin and Pradimicin Antibiotics
Benanomicinones
Benanomicins
Benanomicins and Pradimicins
Pradimicin Antibiotics
Pradimicin Like Polyketides
Pradimicin Type Polyphenols
Pradimicin and Benanomicin Antibiotics
Pradimicin-Like Polyketides
Pradimicin-Type Polyphenols
Pradimicinones
Pradimicins

Tree number(s):

D02.455.426.559.847.562.050.825
D02.540.576.750
D02.806.550.469
D04.345.674.750
D04.615.562.050.825
D09.408.051.059.825

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000095643

Scope note:

Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.

Allowable Qualifiers:

AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine

Concept UI	M000758716
Scope note	Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
Preferred term	Pradimicins and Benanomicins
Entry term(s)	Benanomicins and Pradimicins Pradimicin Like Polyketides Pradimicin Type Polyphenols Pradimicin-Like Polyketides Pradimicin-Type Polyphenols

Concept UI	M000758719
Preferred term	Benanomicin Antibiotics
Entry term(s)	Benanomicins

Concept UI	M000758717
Preferred term	Pradimicin and Benanomicin Antibiotics
Entry term(s)	Benanomicin and Pradimicin Antibiotics

Concept UI	M000758718
Preferred term	Pradimicin Antibiotics
Entry term(s)	Pradimicins

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