| Descriptor English: | Mice, Inbred CFTR | ||||||
| Descriptor Spanish: |
Ratones Endogámicos CFTR
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| Descriptor Portuguese: | Camundongos Endogâmicos CFTR | ||||||
| Descriptor French: | Souris de lignée CFTR | ||||||
| Entry term(s): |
CFTR Mice CFTR Mice, Inbred CFTR Mouse CFTR Mouse, Inbred Inbred CFTR Mice Inbred CFTR Mouse Mice, CFTR Mouse, CFTR Mouse, Inbred CFTR |
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| Tree number(s): |
B01.050.050.199.520.520.445 B01.050.150.900.649.313.992.635.505.500.400.445 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018181 | ||||||
| Scope note: | A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands. |
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| Annotation: | NIM with no qualifiers when experimental animal |
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| Allowable Qualifiers: |
AB abnormalities AH anatomy & histology BL blood CF cerebrospinal fluid CL classification EM embryology GD growth & development GE genetics IM immunology IN injuries ME metabolism MI microbiology PH physiology PS parasitology PX psychology SU surgery UR urine VI virology |
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| Previous Indexing: |
Mice (1992-1993) |
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| Public MeSH Note: | 94 |
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| History Note: | 94 |
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| DeCS ID: | 31310 | ||||||
| Unique ID: | D018181 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1994/01/01 | ||||||
| Date of Entry: | 1993/06/03 | ||||||
| Revision Date: | 2017/07/11 |
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ORGANISMS
Eukaryota [B01]Eukaryota -
ORGANISMS
Eukaryota [B01]Eukaryota
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Mice, Inbred CFTR
- Preferred
| Concept UI |
M0027408 |
| Scope note | A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands. |
| Preferred term | Mice, Inbred CFTR |
| Entry term(s) |
CFTR Mice CFTR Mice, Inbred CFTR Mouse CFTR Mouse, Inbred Inbred CFTR Mice Inbred CFTR Mouse Mice, CFTR Mouse, CFTR Mouse, Inbred CFTR |
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