| Descriptor English: | Mice, Inbred MRL lpr | ||||||
| Descriptor Spanish: |
Ratones Endogámicos MRL lpr
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| Descriptor Portuguese: | Camundongos Endogâmicos MRL lpr | ||||||
| Descriptor French: | Souris de lignée MRL lpr | ||||||
| Entry term(s): |
MRL lpr Mice MRL lpr Mouse Mice, MRL lpr Mouse, Inbred MRL lpr Mouse, MRL lpr |
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| Tree number(s): |
B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019463 | ||||||
| Scope note: | A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents. |
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| Annotation: | NIM with no qualifiers when experimental animal |
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| Allowable Qualifiers: |
AB abnormalities AH anatomy & histology BL blood CF cerebrospinal fluid CL classification EM embryology GD growth & development GE genetics IM immunology IN injuries ME metabolism MI microbiology PH physiology PS parasitology PX psychology SU surgery UR urine VI virology |
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| Previous Indexing: |
Mice (1981-1996) |
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| Public MeSH Note: | 97 |
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| History Note: | 97 |
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| DeCS ID: | 32887 | ||||||
| Unique ID: | D019463 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/19 | ||||||
| Revision Date: | 2017/07/11 |
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ORGANISMS
Eukaryota [B01]Eukaryota -
ORGANISMS
Eukaryota [B01]Eukaryota
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Mice, Inbred MRL lpr
- Preferred
| Concept UI |
M0028954 |
| Scope note | A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents. |
| Preferred term | Mice, Inbred MRL lpr |
| Entry term(s) |
MRL lpr Mice MRL lpr Mouse Mice, MRL lpr Mouse, Inbred MRL lpr Mouse, MRL lpr |
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