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Descriptor English: Leukotriene A4
Descriptor Spanish: Leucotrieno A4
Descriptor leucotrieno A4
Entry term(s) LTA4
Scope note: Ácido (2S-(2 alfa,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-tetradecatetraenil)oxiranebutanoico. Epóxido alílico inestable formado a partir del precursor inmediato 5-HPETE por la retirada estéreo específica de un protón en C-10 y deshidratación. Sus acciones biológicas vienen determinadas principalmente por sus metabolitos, es decir, el LEUCOTRIENO B4 y cisteinil-leucotrienos. Otra posibilidad, el leucotrieno A4 es convertido a LEUCOTRIENO C4 por la glutatión-S-transferasa o a 5,6-di-HETE por la epóxido hidrolasa. (Dictionary of Prostaglandins and Related Compounds, 1990)
Descriptor Portuguese: Leucotrieno A4
Descriptor French: Leucotriène A4
Entry term(s): LTA4
Leukotriene A
Leukotriene A 4
Leukotriene A-4
Leukotrienes A
Tree number(s): D10.251.355.255.100.450.405
D10.251.355.310.166.887.405
D23.469.050.175.450.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017572
Scope note: (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Arachidonic Acids (1980-1988)
Leukotrienes (1989-1993)
Public MeSH Note: 94; LEUKOTRIENE A was indexed under LEUKOTRIENES 1989-93 & ARACHIDONIC ACIDS 1980-88
Online Note: use LEUKOTRIENE A4 (NM) to search LEUKOTRIENE A 1980-93
History Note: 94; was LEUKOTRIENE A (NM) 1980-93
DeCS ID: 31351
Unique ID: D017572
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2015/06/08
Leukotriene A4 - Preferred
Concept UI M0026633
Scope note (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Preferred term Leukotriene A4
Entry term(s) LTA4
Leukotriene A 4
Leukotriene A-4
Leukotriene A - Broader
Concept UI M0026634
Preferred term Leukotriene A
Entry term(s) Leukotrienes A



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