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Descriptor English: Electron Transport Complex IV
Descriptor Spanish: Complejo IV de Transporte de Electrones
Descriptor Portuguese: Complexo IV da Cadeia de Transporte de Elétrons
Descriptor French: Complexe IV de la chaîne respiratoire
Entry term(s): Cytochrome Oxidase
Cytochrome Oxidase Subunit III
Cytochrome a,a3
Cytochrome aa3
Cytochrome c Oxidase
Cytochrome c Oxidase Subunit III
Cytochrome c Oxidase Subunit IV
Cytochrome c Oxidase Subunit VIa
Cytochrome-c Oxidase
Cytochrome-c Oxidase (Complex IV)
Cytochrome-c Oxidase Subunit III
Cytochrome-c Oxidase Subunit IV
Ferrocytochrome c Oxygen Oxidoreductase
Heme aa3 Cytochrome Oxidase
Oxidase, Cytochrome
Oxidase, Cytochrome-c
Pre-CTOX p25
Signal Peptide p25 Subunit IV Cytochrome Oxidase
Signal Peptide p25-Subunit IV Cytochrome Oxidase
Subunit III, Cytochrome Oxidase
p25 Presequence Peptide Cytochrome Oxidase
p25 Presequence Peptide-Cytochrome Oxidase
Tree number(s): D05.500.562.374
D08.811.600.250.687
D08.811.682.285
D12.776.157.530.450.250.875.304
D12.776.543.277.687
D12.776.543.585.450.250.875.484
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003576
Scope note: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Annotation: spell in titles & translations with lowercase c: cytochrome-c oxidase
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Cytochrome-c Oxidase Deficiency
Registry Number: EC 1.9.3.1
CAS Type 1 Name: Ferricytochrome-c:oxygen oxidoreductase
Public MeSH Note: 2004; see CYTOCHROME-C OXIDASE 1994-2003, see CYTOCHROME C OXIDASE 1992-1993, see CYTOCHROME OXIDASE 1963-1991; for CYTOCHROME C OXIDASE see CYTOCHROME OXIDASE 1984-1991; SIGNAL PEPTIDE P25-SUBUNIT IV CYTOCHROME OXIDASE was indexed under CYTOCHROME C OXIDASE 1988-2001; CYTOCHROME OXIDASE SUBUNIT III was indexed under CYTOCHROME C OXIDASE 1998-2001
History Note: 2004(1963); for SIGNAL PEPTIDE P25-SUBUNIT IV CYTOCHROME OXIDASE use CYTOCHROME C OXIDASE (NM) 1988-2001; for CYTOCHROME OXIDASE SUBUNIT III use CYTOCHROME C OXIDASE (NM) 1998-2001
Related: Cytochrome-c Oxidase Deficiency MeSH
DeCS ID: 31728
Unique ID: D003576
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09
Electron Transport Complex IV - Preferred
Concept UI M0005587
Scope note A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Preferred term Electron Transport Complex IV
Entry term(s) Cytochrome Oxidase
Cytochrome c Oxidase
Cytochrome-c Oxidase
Cytochrome-c Oxidase (Complex IV)
Ferrocytochrome c Oxygen Oxidoreductase
Oxidase, Cytochrome
Oxidase, Cytochrome-c
Signal Peptide p25-Subunit IV Cytochrome Oxidase - Narrower
Concept UI M0005588
Preferred term Signal Peptide p25-Subunit IV Cytochrome Oxidase
Entry term(s) Pre-CTOX p25
Signal Peptide p25 Subunit IV Cytochrome Oxidase
p25 Presequence Peptide Cytochrome Oxidase
p25 Presequence Peptide-Cytochrome Oxidase
Cytochrome-c Oxidase Subunit III - Narrower
Concept UI M0005590
Preferred term Cytochrome-c Oxidase Subunit III
Entry term(s) Cytochrome Oxidase Subunit III
Cytochrome c Oxidase Subunit III
Subunit III, Cytochrome Oxidase
Cytochrome-c Oxidase Subunit IV - Narrower
Concept UI M0333367
Preferred term Cytochrome-c Oxidase Subunit IV
Entry term(s) Cytochrome c Oxidase Subunit IV
Cytochrome aa3 - Narrower
Concept UI M0447606
Scope note A dimer of CYTOCHROME A and CYTOCHROME A3.
Preferred term Cytochrome aa3
Entry term(s) Cytochrome a,a3
Heme aa3 Cytochrome Oxidase
Cytochrome c Oxidase Subunit VIa - Narrower
Concept UI M0365809
Preferred term Cytochrome c Oxidase Subunit VIa



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