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Descriptor English: DNA Topoisomerases, Type II
Descriptor Spanish: ADN-Topoisomerasas de Tipo II
Descriptor ADN-topoisomerasas de tipo II
Entry term(s) ADN topoisomerasa (hidrolizante de ATP)
ADN topoisomerasa II
ADN topoisomerasa bacteriana tipo II
ADN topoisomerasas de tipo II
ADN topoisomerasas tipo II
topoisomerasa de ADN bacteriana tipo II
topoisomerasas de ADN tipo II bacteianas
Scope note: ADN TOPOISOMERASAS que catalizan la ruptura dependiente de ATP de ambas hebras del ADN, el paso de hebras intactas a su través y la unión de nuevo de las hebras rotas. Estas enzimas reducen la tensión del ADN superenrollado y resuelven los nudos de ADN bicatenario circular.
Descriptor Portuguese: DNA Topoisomerases Tipo II
Descriptor French: ADN topoisomérases de type II
Entry term(s): DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II
DNA Topoisomerase II alpha
DNA Topoisomerase II beta
DNA Type 2 Topoisomerase
TOP2A Protein
TOP2B Protein
Topoisomerase II
Topoisomerase II alpha
Topoisomerase II beta
Type II DNA Topoisomerase
alpha, Topoisomerase II
beta, Topoisomerase II
Tree number(s): D08.811.399.403.741
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004250
Scope note: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Topoisomerase II Inhibitors
Registry Number: EC 5.99.1.3
Previous Indexing: DNA (1966-1977)
DNA Replication (1968-1979)
DNA Untwisting Proteins (1978-1979)
DNA, Superhelical (1978-1979)
Public MeSH Note: 2018; see DNA TOPOISOMERASE (ATP-HYDROLYSING) 1994-2001, see DNA GYRASE 1980-1993; DNA TOPOISOMERASE II ALPHA was indexed under ANTIGENS, NEOPLASM; DNA TOPOSIOMERASES, TYPE II, and DNA-BINDING PROTEINS 2002-2017; and under DNA TOPOISOMERASE (ATP-HYDROLYSING) 1992-2001; DNA TOPOISOMERASE II BETA was indexed under DNA TOPOISOMERASES, TYPE II and DNA-BINDING PROTEINS 2002-2017
History Note: 2018(2002); use DNA GYRASE 1980-1993
DeCS ID: 31731
Unique ID: D004250
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1979/05/23
Revision Date: 2017/07/03
DNA Topoisomerases, Type II - Preferred
Concept UI M0381050
Scope note DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Preferred term DNA Topoisomerases, Type II
Entry term(s) DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II
DNA Type 2 Topoisomerase
Topoisomerase II
Type II DNA Topoisomerase
DNA Topoisomerase II beta - Narrower
Concept UI M0232608
Preferred term DNA Topoisomerase II beta
Entry term(s) TOP2B Protein
Topoisomerase II beta
beta, Topoisomerase II
DNA Topoisomerase II alpha - Narrower
Concept UI M0232605
Preferred term DNA Topoisomerase II alpha
Entry term(s) TOP2A Protein
Topoisomerase II alpha
alpha, Topoisomerase II



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