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Descriptor English: DNA Topoisomerase IV
Descriptor Spanish: Topoisomerasa de ADN IV
Descriptor ADN topoisomerasa IV
Entry term(s) proteína parC
proteína parE
Scope note: Topoisomerasa bacteriana de ADN II que cataliza la rotura dependiente de ATP de ambas hebras de ADN, el paso de hebras sin romper a través de las roturas y la unión, de nuevo, de las hebras rotas. La topoisomerasa IV se une al ADN como heterodímero que consta de dos subunidades parC y 2 subunidades parE. La topoisomerasa IV es una enzima separadora de los cromosmas hijos entrelazados tras la replicación del ADN.
Descriptor Portuguese: DNA Topoisomerase IV
Descriptor French: DNA topoisomerase IV
Entry term(s): Topo IV
Topoisomerase IV
Topoisomerase IV Subunit A
Topoisomerase IV Subunit B
Topoisomerase IV, DNA
parC Gene Product
parC Gene Product, Topo IV
parC Protein
parE Gene Product
parE Gene Product, Topo IV
parE Protein
Tree number(s): D08.811.399.403.741.224
D12.776.097.256
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D027101
Scope note: A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 5.99.1.-
Previous Indexing: DNA Topoisomerase (1990-1995)
DNA Topoisomerase (ATP-Hydrolysing) (1991-2001)
Public MeSH Note: 2002; DNA TOPOISOMERASE IV was indexed under TYPE II DNA TOPOISOMERASE 1991-2001
History Note: 2002; use DNA TOPOISOMERASE IV (NM) 1991-2001
DeCS ID: 36090
Unique ID: D027101
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2010/06/25
DNA Topoisomerase IV - Preferred
Concept UI M0181519
Scope note A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Preferred term DNA Topoisomerase IV
Entry term(s) Topo IV
Topoisomerase IV
Topoisomerase IV, DNA
parC Protein - Narrower
Concept UI M0379539
Scope note One of the two subunits in DNA topoisomerase IV.
Preferred term parC Protein
Entry term(s) Topoisomerase IV Subunit A
parC Gene Product
parC Gene Product, Topo IV
parE Protein - Narrower
Concept UI M0210672
Scope note One of the two subunits in DNA topoisomerase IV.
Preferred term parE Protein
Entry term(s) Topoisomerase IV Subunit B
parE Gene Product
parE Gene Product, Topo IV



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