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Descriptor English: DNA Topoisomerases
Descriptor Spanish: ADN-Topoisomerasas
Descriptor ADN-topoisomerasas
Entry term(s) ADN topoisomerasas
Scope note: Enzimas que regulan la topología del ADN mediante acciones como la rotura, relajación, paso y reunión de las cadenas de ADN en las células. Estas enzimas son componentes importantes del sistema de replicación del ADN. Se clasifican por la especificidad del sustrato. Las ADN TOPOISOMERASAS DE TIPO I actúan sobre una cadena única del ADN. Las ADN TOPOISOMERASAS DE TIPO II actuan sobre cadenas dobles de ADN.
Descriptor Portuguese: DNA Topoisomerases
Descriptor French: DNA topoisomerases
Entry term(s): Topoisomerases, DNA
Tree number(s): D08.811.399.403
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D026942
Scope note: Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Topoisomerase Inhibitors
Registry Number: EC 5.99.1.-
Previous Indexing: DNA Topoisomerase (1977-2001)
DNA Topoisomerase (ATP-Hydrolysing) (1979-2001)
Public MeSH Note: 2002
History Note: 2002
DeCS ID: 36083
Unique ID: D026942
NLM Classification: QU 137
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2010/06/25
DNA Topoisomerases - Preferred
Concept UI M0379272
Scope note Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.
Preferred term DNA Topoisomerases
Entry term(s) Topoisomerases, DNA



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