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Descriptor English: DNA Topoisomerases, Type I
Descriptor Spanish: ADN-Topoisomerasas de Tipo I
Descriptor Portuguese: DNA Topoisomerases Tipo I
Descriptor French: ADN topoisomérases de type I
Entry term(s): DNA Nicking-Closing Protein
DNA Nicking-Closing Proteins
DNA Relaxing Enzyme
DNA Relaxing Enzymes
DNA Relaxing Protein
DNA Topoisomerase
DNA Topoisomerase I
DNA Topoisomerase III
DNA Topoisomerase III alpha
DNA Topoisomerase III beta
DNA Type 1 Topoisomerase
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
III beta, Topoisomerase
III, DNA Topoisomerase
III, Topo
III, Topoisomerase
IIIalpha, TOPO
IIIalpha, Topoisomerase
IIIbeta, Topoisomerase
TOP3 Topoisomerase
TOP3alpha
TOPO IIIalpha
Topo III
Topoisomerase I
Topoisomerase III
Topoisomerase III beta
Topoisomerase III, DNA
Topoisomerase IIIalpha
Topoisomerase IIIbeta
Topoisomerase, TOP3
Type I DNA Topoisomerase
beta, Topoisomerase III
Tree number(s): D08.811.399.403.483
D12.776.157.687.375
D12.776.660.720.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004264
Scope note: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Annotation: do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Topoisomerase I Inhibitors
Registry Number: EC 5.99.1.2
CAS Type 1 Name: DNA topoisomerase
Previous Indexing: DNA, Circular (1973-1977)
Deoxyribonucleases (1966-1977)
Polynucleotide Synthetases (1973-1977)
Proteins (1966-1977)
specific protein (1966-1977)
Public MeSH Note: 2002; see DNA TOPOISOMERASE 1994-2001, see DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN see DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME see DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME see DNA UNTWISTING ENZYMES 1978-1993
History Note: 2002
DeCS ID: 31732
Unique ID: D004264
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/04/15
Revision Date: 2019/07/08
DNA Topoisomerases, Type I - Preferred
Concept UI M0381011
Scope note DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Preferred term DNA Topoisomerases, Type I
Entry term(s) DNA Nicking-Closing Protein
DNA Nicking-Closing Proteins
DNA Relaxing Enzyme
DNA Relaxing Enzymes
DNA Relaxing Protein
DNA Topoisomerase
DNA Topoisomerase I
DNA Type 1 Topoisomerase
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
Topoisomerase I
Type I DNA Topoisomerase
DNA Topoisomerase III alpha - Narrower
Concept UI M000649950
Preferred term DNA Topoisomerase III alpha
Entry term(s) IIIalpha, TOPO
IIIalpha, Topoisomerase
TOP3alpha
TOPO IIIalpha
Topoisomerase IIIalpha
DNA Topoisomerase III beta - Narrower
Concept UI M000649951
Preferred term DNA Topoisomerase III beta
Entry term(s) III beta, Topoisomerase
IIIbeta, Topoisomerase
Topoisomerase III beta
Topoisomerase IIIbeta
beta, Topoisomerase III
DNA Topoisomerase III - Narrower
Concept UI M000649952
Preferred term DNA Topoisomerase III
Entry term(s) III, DNA Topoisomerase
III, Topo
III, Topoisomerase
TOP3 Topoisomerase
Topo III
Topoisomerase III
Topoisomerase III, DNA
Topoisomerase, TOP3



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