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Descriptor English: Peptidyl-Dipeptidase A
Descriptor Spanish: Peptidil-Dipeptidasa A
Descriptor peptidil-dipeptidasa A
Entry term(s) ECA1, enzima convertidora de la angiotensina 1
antígenos CD143
cininasa II
enzima convertidora de angiotensina
enzima convertidora de la angiotensina 1
proteína ECA1
Scope note: Peptidil-dipeptidasa que cataliza la liberación de un dipéptido C-terminal, oligopéptido-|-Xaa-Yaa, cuando Xaa no es Pro y Yaa no es Asp ni Glu. Por lo tanto, cataliza la conversión de ANGIOTENSINA I a ANGIOTENSINA II, con aumento de la actividad vasoconstrictora, pero no tiene acción sobre la angiotensina II. También es capaz de inactivar la BRADICININA, un potente vasodilatador, y tiene una actividad glicosidasa que libera proteínas ancladas a GPI de la membrana escindiendo el enlace manosa en el resto de GPI. (Traducción libre del original: https://www.uniprot.org el 15 de abril de 2020).
Descriptor Portuguese: Peptidil Dipeptidase A
Descriptor French: Peptidyl-Dipeptidase A
Entry term(s): ACE1 Angiotensin Converting Enzyme 1
ACE1 Angiotensin-Converting Enzyme 1
ACE1 Protein
Angiotensin Converting Enzyme
Angiotensin Converting Enzyme 1
Angiotensin I Converting Enzyme
Angiotensin I-Converting Enzyme
Antigens, CD143
CD143 Antigens
Carboxycathepsin
Dipeptidyl Carboxypeptidase I
Dipeptidyl Peptidase A
Kininase A
Kininase II
Peptidase P
Peptidyl Dipeptidase A
Tree number(s): D08.811.277.656.350.350.687
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007703
Scope note: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-*-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Angiotensin-Converting Enzyme Inhibitors
Registry Number: EC 3.4.15.1
Previous Indexing: Peptide Peptidohydrolases (1966-1972)
Public MeSH Note: 1994; see KININASE II 1974-93; for TONIN see KININASE II 1984-93
History Note: 1994; for TONIN use KININASE II 1984-93
DeCS ID: 31868
Unique ID: D007703
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/06/09
Peptidyl-Dipeptidase A - Preferred
Concept UI M0012049
Scope note A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-*-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020)
Preferred term Peptidyl-Dipeptidase A
Entry term(s) ACE1 Angiotensin Converting Enzyme 1
ACE1 Angiotensin-Converting Enzyme 1
ACE1 Protein
Angiotensin Converting Enzyme
Angiotensin Converting Enzyme 1
Angiotensin I Converting Enzyme
Angiotensin I-Converting Enzyme
Antigens, CD143
CD143 Antigens
Carboxycathepsin
Dipeptidyl Carboxypeptidase I
Dipeptidyl Peptidase A
Kininase A
Kininase II
Peptidase P
Peptidyl Dipeptidase A



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