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Descriptor English: Protein S Deficiency
Descriptor Spanish: Deficiencia de Proteína S
Descriptor Portuguese: Deficiência de Proteína S
Descriptor French: Déficit en protéine S
Entry term(s): Deficiencies, Protein S
Deficiency, Protein S
Hereditary Thrombophilia Due To Protein S Deficiency
Protein S Deficiencies
Tree number(s): C15.378.100.800
C15.378.147.890
C15.378.925.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018455
Scope note: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Annotation:
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Glycoproteins/deficiency (1984-1992)
Protein S/deficiency (1993-1994)
Public MeSH Note: 95
History Note: 95
Entry Version: PROTEIN S DEFIC
DeCS ID: 32063
Unique ID: D018455
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/04/16
Revision Date: 2013/07/08
Protein S Deficiency - Preferred
Concept UI M0027690
Scope note An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Preferred term Protein S Deficiency
Entry term(s) Deficiencies, Protein S
Deficiency, Protein S
Hereditary Thrombophilia Due To Protein S Deficiency
Protein S Deficiencies



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