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Descriptor English: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Descriptor Spanish: Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
Descriptor espectrometría de masas con desorción-ionización láser asistida por matriz
Entry term(s) MALD-MS
MALDI
espectrometría de masas de ionización desorción por láser de matriz asistida
espectroscopía de masas por láser de matriz asistida de ionización desorción
Scope note: Técnica de espectrometría de masas que se emplea para el análisis de grandes biomoléculas. Se embeben moléculas de analito en una matriz excedente de pequeñas moléculas orgánicas que muestran una absorción altamente resonante en la longitud de onda láser empleada. La matriz absorbe la energía del láser, induciendo así una suave desintegración de la mezcla muestra-matriz hacia matriz libre (fase de gas) y moléculas de analito e iones moleculares. En general, sólo se producen iones moleculares de las moléculas de analito, y casi no se produce fragmentación. Esto hace que el método sea muy apropiado para determinaciones del peso molecular y análisis de mezclas.
Descriptor Portuguese: Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Descriptor French: Spectrométrie de masse MALDI
Entry term(s): Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
MALD-MS
MALDI
MALDI MS
MALDI-MS
MS-MALD
Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
Matrix Assisted Laser Desorption Ionization Mass Spectrometry
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
SELDI-TOF-MS
Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
Surface Enhanced Laser Desorption Ionization Mass Spectrometry
Tree number(s): E05.196.566.755
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019032
Scope note: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Allowable Qualifiers: CL classification
EC economics
ES ethics
HI history
IS instrumentation
MT methods
SN statistics & numerical data
ST standards
TD trends
VE veterinary
Previous Indexing: Spectrum Analysis, Mass (1989-1995)
Public MeSH Note: 96
History Note: 96
DeCS ID: 32607
Unique ID: D019032
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2006/07/05
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - Preferred
Concept UI M0028408
Scope note A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Preferred term Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Entry term(s) Laser Desorption Ionization Mass Spectrometry, Matrix Assisted
Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
MALD-MS
MALDI
MALDI MS
MALDI-MS
MS-MALD
Mass Spectrometry, Matrix Assisted Laser Desorption Ionization
Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization
Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
Matrix Assisted Laser Desorption Ionization Mass Spectrometry
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
Surface Enhanced Laser Desorption Ionization Mass Spectrometry - Narrower
Concept UI M0471101
Scope note A technique incorporating MALDI that uses ultraviolet absorbing organic molecules (matrix) to transfer energy from a LASERS to an analyte for desorption and ionization. It is useful for PROTEIN ARRAY ANALYSIS.
Preferred term Surface Enhanced Laser Desorption Ionization Mass Spectrometry
Entry term(s) SELDI-TOF-MS



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