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Descriptor English: Antineoplastic Agents, Alkylating
Descriptor Spanish: Antineoplásicos Alquilantes
Descriptor Portuguese: Antineoplásicos Alquilantes
Descriptor French: Antinéoplasiques alcoylants
Entry term(s): Alkylating Agents, Antineoplastic
Alkylating Antineoplastic Agents
Alkylating Antineoplastic Drugs
Alkylating Antineoplastics
Alkylating Drugs, Antineoplastic
Antineoplastic Alkylating Agents
Antineoplastic Alkylating Drugs
Antineoplastic Drugs, Alkylating
Antineoplastics, Alkylating
Drugs, Antineoplastic Alkylating
Tree number(s): D27.505.519.124.035
D27.505.954.248.150
D27.888.569.035.035
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018906
Scope note: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Alkylating Agents (1966-1995)
Antineoplastic Agents (1966-1995)
Public MeSH Note: 96
History Note: 96
Entry Version: ANTINEOPL AGENTS ALKYLATING
DeCS ID: 32836
Unique ID: D018906
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2014/06/25
Antineoplastic Agents, Alkylating - Preferred
Concept UI M0028268
Scope note A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Preferred term Antineoplastic Agents, Alkylating
Entry term(s) Alkylating Agents, Antineoplastic
Alkylating Antineoplastic Agents
Alkylating Antineoplastic Drugs
Alkylating Antineoplastics
Alkylating Drugs, Antineoplastic
Antineoplastic Alkylating Agents
Antineoplastic Alkylating Drugs
Antineoplastic Drugs, Alkylating
Antineoplastics, Alkylating
Drugs, Antineoplastic Alkylating



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