| Descriptor English: | Antineoplastic Agents, Alkylating | ||||||
| Descriptor Spanish: |
Antineoplásicos Alquilantes
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| Descriptor Portuguese: | Antineoplásicos Alquilantes | ||||||
| Descriptor French: | Antinéoplasiques alcoylants | ||||||
| Entry term(s): |
Alkylating Agents, Antineoplastic Alkylating Antineoplastic Agents Alkylating Antineoplastic Drugs Alkylating Antineoplastics Alkylating Drugs, Antineoplastic Antineoplastic Alkylating Agents Antineoplastic Alkylating Drugs Antineoplastic Drugs, Alkylating Antineoplastics, Alkylating Drugs, Antineoplastic Alkylating |
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| Tree number(s): |
D27.505.519.124.035 D27.505.954.248.150 D27.888.569.035.035 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018906 | ||||||
| Scope note: | A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Previous Indexing: |
Alkylating Agents (1966-1995) Antineoplastic Agents (1966-1995) |
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| Public MeSH Note: | 96 |
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| History Note: | 96 |
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| Entry Version: | ANTINEOPL AGENTS ALKYLATING |
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| DeCS ID: | 32836 | ||||||
| Unique ID: | D018906 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1996/01/01 | ||||||
| Date of Entry: | 1995/05/26 | ||||||
| Revision Date: | 2014/06/25 |
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CHEMICALS AND DRUGS
Chemical Actions and Uses [D27]Chemical Actions and Uses -
CHEMICALS AND DRUGS
Chemical Actions and Uses [D27]Chemical Actions and Uses -
CHEMICALS AND DRUGS
Chemical Actions and Uses [D27]Chemical Actions and Uses
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Antineoplastic Agents, Alkylating
- Preferred
| Concept UI |
M0028268 |
| Scope note | A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) |
| Preferred term | Antineoplastic Agents, Alkylating |
| Entry term(s) |
Alkylating Agents, Antineoplastic Alkylating Antineoplastic Agents Alkylating Antineoplastic Drugs Alkylating Antineoplastics Alkylating Drugs, Antineoplastic Antineoplastic Alkylating Agents Antineoplastic Alkylating Drugs Antineoplastic Drugs, Alkylating Antineoplastics, Alkylating Drugs, Antineoplastic Alkylating |
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