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Descriptor English: Antineoplastic Agents, Alkylating
Descriptor Spanish: Antineoplásicos Alquilantes
Descriptor antineoplásicos alquilantes
Entry term(s) agentes alquilantes antineoplásicos
agentes antineoplásicos alquilantes
alquilante antineoplásico
alquilantes antineoplásicos
antineoplásico alquilante
Scope note: Clase de fármacos que se diferencian de otros alquilantes que se utilizan en la clínica en que son monofuncionales y por tanto incapaces de formar enlaces cruzados con macromoléculas celulares. Entre sus propiedades comunes están la necesidad de activación metabólica de intermediarios con eficacia antitumoral, y la presencia en su estructura química de grupos N-metilo que, una vez metabolizados, pueden modificar covalentemente el ADN celular. No se conocen por completo los mecanismos precisos por los cuales cada uno de estos fármacos destruye las células tumorales. (AMA, Drug Evaluations Annual, 1994, p. 2026)
Descriptor Portuguese: Antineoplásicos Alquilantes
Descriptor French: Antinéoplasiques alcoylants
Entry term(s): Agents anticancéreux alkylants
Anticancéreux alcoylants
Anticancéreux alkylants
Antinéoplasiques alkylants
Tree number(s): D27.505.519.124.035
D27.505.954.248.150
D27.888.569.035.035
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018906
Scope note: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
DeCS ID: 32836
Unique ID: D018906
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2014/06/25
Antinéoplasiques alcoylants - Preferred
Concept UI M0028268
Preferred term Antinéoplasiques alcoylants
Entry term(s) Agents anticancéreux alkylants
Anticancéreux alcoylants
Anticancéreux alkylants
Antinéoplasiques alkylants



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