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Descriptor English: Staurosporine
Descriptor Spanish: Estaurosporina
Descriptor estauroporina
Entry term(s) (8-alfa,9-beta,10-beta,12-alfa)-(+)-2,3,9,10,11,12-hexahidro-9-metoxi-8-metil-10-(metilamino)-8,12-epoxi-1H,8H-2,7b,12a-triazadibenzo(a,g)ciclonona(cde)trinden-1-ona
Scope note: Indolocarbazol, inhibidor potente de la PROTEINA QUINASA C, que aumenta las respuestas mediadas por AMPc en las células de neuroblastoma humano (Biochem Biophys Res Commun 1995;214(3):1114-20).
Descriptor Portuguese: Estaurosporina
Descriptor French: Staurosporine
Tree number(s): D03.132.436.750
D03.633.100.473.144.750
D03.633.100.473.402.750
D03.633.100.496.500.500.750
D03.633.300.148.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019311
Scope note: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Enzyme Inhibitors
Registry Number: H88EPA0A3N
CAS Type 1 Name: 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
DeCS ID: 32990
Unique ID: D019311
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2019/02/22
Staurosporine - Preferred
Concept UI M0028755
Preferred term Staurosporine



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