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Descriptor English: Clavulanic Acid
Descriptor Spanish: Ácido Clavulánico
Descriptor ácido clavulánico
Entry term(s) clavulanato
Scope note: Antibiótico betalactámico producido por la actinobacteria Streptomyces clavuligerus. Es un inhibidor suicida de las enzimas betalactamasas bacterianas. Administrado solo tiene únicamente actividad antibacteriana débil contra la mayoría de los microorganismos, pero en combinación con otros antibióticos betalactámicos previene la inactivación del antibiótico por las lactamasas bacterianas.
Descriptor Portuguese: Ácido Clavulânico
Descriptor French: Acide clavulanique
Entry term(s): BRL 14151
BRL-14151
BRL14151
Clavulanate
Clavulanate Potassium
Clavulanate, Potassium
Clavulanate, Sodium
Clavulanic Acid, Monopotassium Salt
Clavulanic Acid, Monosodium Salt
MM 14151
MM-14151
MM14151
Potassium Clavulanate
Potassium, Clavulanate
Sodium Clavulanate
Tree number(s): D02.065.589.099.374.160
D03.633.100.300.374.160
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019818
Scope note: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Entry Combination: analogs & derivatives:Clavulanic Acids
Pharm Action: beta-Lactamase Inhibitors
Registry Number: 23521W1S24
CAS Type 1 Name: 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))
Previous Indexing: Clavulanic Acids (1978-1997)
Lactams (1976-1982)
Public MeSH Note: 98; CLAVULANIC ACID was indexed under CLAVULANIC ACIDS 1978-97 & LACTAMS 1976-82
History Note: 98; use CLAVULANIC ACID (NM) 1980-97
DeCS ID: 33383
Unique ID: D019818
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2018/06/29
Clavulanic Acid - Preferred
Concept UI M0029416
Scope note A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Preferred term Clavulanic Acid
MM-14151 - Narrower
Concept UI M0372714
Preferred term MM-14151
Entry term(s) MM 14151
MM14151
Clavulanate Potassium - Narrower
Concept UI M0329136
Preferred term Clavulanate Potassium
Entry term(s) Clavulanate, Potassium
Clavulanic Acid, Monopotassium Salt
Potassium Clavulanate
Potassium, Clavulanate
Clavulanic Acid, Monosodium Salt - Narrower
Concept UI M0329135
Preferred term Clavulanic Acid, Monosodium Salt
Entry term(s) Clavulanate, Sodium
Sodium Clavulanate
BRL-14151 - Narrower
Concept UI M0372715
Preferred term BRL-14151
Entry term(s) BRL 14151
BRL14151
Clavulanate - Narrower
Concept UI M0372713
Preferred term Clavulanate



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