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Descriptor English: Clavulanic Acids
Descriptor Spanish: Ácidos Clavulánicos
Descriptor Portuguese: Ácidos Clavulânicos
Descriptor French: Acides clavulaniques
Entry term(s): Acids, Clavulanic
Tree number(s): D02.065.589.099.374
D03.633.100.300.374
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002969
Scope note: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Annotation: /biosyn permitted if by living matter
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Enzyme Inhibitors
Previous Indexing: Amides (1966-1973)
Amidohydrolases (1966-1978)
Lactams (1974-1982)
Penicillinase (1966-1978)
beta-Lactamases (1979-1982)
Public MeSH Note: 83
History Note: 83
DeCS ID: 2994
Unique ID: D002969
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/05/05
Revision Date: 2016/05/28
Clavulanic Acids - Preferred
Concept UI M0004546
Scope note Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Preferred term Clavulanic Acids
Entry term(s) Acids, Clavulanic



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