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Descriptor English: Clavulanic Acids
Descriptor Spanish: Ácidos Clavulánicos
Descriptor ácidos clavulánicos
Scope note: Ácidos, sales y derivados del ácido clavulánico (C8H905N). Son los compuestos betalactámicos que difieren de la penicilina en que el azufre del anillo tiazolidina ha sido sustituido por oxígeno. Tienen limitada acción antibacteriana pero bloquean irrversiblemente la betalactamasa bacteriana con lo que otros antibióticos no son destruidos por las enzimas bacterianas y pueden, así, ejercer sus efectos antibacterianos.
Descriptor Portuguese: Ácidos Clavulânicos
Descriptor French: Acides clavulaniques
Entry term(s): Acids, Clavulanic
Tree number(s): D02.065.589.099.374
D03.633.100.300.374
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002969
Scope note: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Annotation: /biosyn permitted if by living matter
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Enzyme Inhibitors
Previous Indexing: Amides (1966-1973)
Amidohydrolases (1966-1978)
Lactams (1974-1982)
Penicillinase (1966-1978)
beta-Lactamases (1979-1982)
Public MeSH Note: 83
History Note: 83
DeCS ID: 2994
Unique ID: D002969
NLM Classification: QV 350
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/05/05
Revision Date: 2016/05/28
Clavulanic Acids - Preferred
Concept UI M0004546
Scope note Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Preferred term Clavulanic Acids
Entry term(s) Acids, Clavulanic



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