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Descriptor English: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
Descriptor Spanish: 3,4-Dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclohexil)-bencenacetamida, (trans)-Isómero
Descriptor 3,4-dicloro-N-metil-N-(2-(pirrolidinil)-ciclohexil)-bencenoacetamida isómero-(trans)
Entry term(s) bencenoacetamida 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)ciclohexil) isómero (trans)
Scope note: Agonista, no peptídico, de los receptores de opioides kappa, que también estimula la liberación de adrenocorticotropina (HORMONA ADRENOCORTICOTRÓPICA) mediante la liberación de vasopresina arginina hipotalámica (ARGININA VASOPRESINA) y la HORMONA LIBERADORA DE CORTICOTROPINA. ( J Pharmacol Exp Ther 1997;280(1):416-21)
Descriptor Portuguese: (trans)-Isômero de 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclo-hexil)-benzenoacetamida
Descriptor French: 2-(3,4-Dichlorophényl)-N-méthyl-N-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)acétamide
Entry term(s): 3,4-Dichloro-N-méthyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzèneacétamide, (trans)-isomère
U-50,488H
U-50488
U-50488H
U50488H
Tree number(s): D03.383.773.170
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019900
Scope note: A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Antihypertensive Agents
Analgesics, Non-Narcotic
Registry Number: 67198-13-4
DeCS ID: 33412
Unique ID: D019900
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2016/05/27
2-(3,4-Dichlorophényl)-N-méthyl-N-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)acétamide - Preferred
Concept UI M0029556
Preferred term 2-(3,4-Dichlorophényl)-N-méthyl-N-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)acétamide
Entry term(s) 3,4-Dichloro-N-méthyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzèneacétamide, (trans)-isomère
U-50488 - Narrower
Concept UI M0369892
Preferred term U-50488
Entry term(s) U-50,488H
U-50488H
U50488H



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