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Descriptor English: Kainic Acid
Descriptor Spanish: Ácido Kaínico
Descriptor ácido kaínico
Entry term(s) kainato
ácido digénico
Scope note: Ácido (2S-(2 alfa,3 beta,4 beta))-2-carboxi-4-(1-metiletenil)-3-pirrolidinacético. Ascaricida que se obtiene a partir del alga roja Digenea simplex. Se trata de un potente agonista de aminoácidos excitatorios en determinados tipos de receptores de aminoácidos excitatorios y se ha utilizado para discriminar tipos de receptores. Al igual que muchos agonistas de amonoácidos excitatorios, puede causar neurotoxicidad, por lo que se ha utilizado experimentalmente con este fin.
Descriptor Portuguese: Ácido Caínico
Descriptor French: Acide kaïnique
Entry term(s): Acid, Digenic
Acid, Kainic
Digenic Acid
Kainate
Tree number(s): D03.383.773.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007608
Scope note: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
Annotation: an antinematodal agent & excitatory amino acid agonist
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antinematodal Agents
Excitatory Amino Acid Agonists
Registry Number: SIV03811UC
CAS Type 1 Name: 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S-(2alpha,3beta,4beta))-
Previous Indexing: Pyrrolidines (1966-1977)
Public MeSH Note: 86; was see under PYRROLIDINES 1978-85
History Note: 86(78); was see under PYRROLIDINES 1978-85
Related: Receptors, Kainic Acid MeSH
DeCS ID: 7777
Unique ID: D007608
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1977/04/22
Revision Date: 2016/05/31
Kainic Acid - Preferred
Concept UI M0011891
Scope note (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
Preferred term Kainic Acid
Entry term(s) Acid, Digenic
Acid, Kainic
Digenic Acid
Kainate - Narrower
Concept UI M0011892
Preferred term Kainate



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