Descriptor English: | Simvastatin | ||||
Descriptor Spanish: |
Simvastatina
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Descriptor Portuguese: | Sinvastatina | ||||
Descriptor French: | Simvastatine | ||||
Entry term(s): |
MK 733 MK-733 MK733 Synvinolin Zocor |
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Tree number(s): |
D02.455.426.559.847.638.400.900 D04.615.638.400.900 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019821 | ||||
Scope note: | A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. |
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Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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Pharm Action: |
Anticholesteremic Agents Anticolesterolemiantes Anticolesterolemiantes Anticholestérolémiants anticolesterolemiantes Hypolipidemic Agents Hipolipemiantes Hipolipemiantes Hypolipémiants hipolipemiantes Hydroxymethylglutaryl-CoA Reductase Inhibitors Inhibidores de Hidroximetilglutaril-CoA Reductasas Inibidores de Hidroximetilglutaril-CoA Redutases Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase inhibidores de las hidroximetilglutaril-CoA reductasas |
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Registry Number: | AGG2FN16EV | ||||
Previous Indexing: |
Lovastatin/analogs & derivatives (1988-1997) Naphthalenes (1986-1987) |
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Public MeSH Note: | 98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87 |
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History Note: | 98; use SIMVASTATIN (NM) 1986-97 |
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Related: |
Rosuvastatin Calcium
MeSH | ||||
DeCS ID: | 33420 | ||||
Unique ID: | D019821 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 1998/01/01 | ||||
Date of Entry: | 1997/06/20 | ||||
Revision Date: | 2017/01/17 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds
|
Simvastatin
- Preferred
Zocor
- Narrower
MK-733
- Narrower
Synvinolin
- Narrower
Concept UI |
M0029425 |
Scope note | A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. |
Preferred term | Simvastatin |
Concept UI |
M0029426 |
Preferred term | Zocor |
Concept UI |
M0350853 |
Preferred term | MK-733 |
Entry term(s) |
MK 733 MK733 |
Concept UI |
M000623516 |
Preferred term | Synvinolin |
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