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Descriptor in English: Lovastatin
Descriptor in Spanish: Lovastatina
Descriptor in Portuguese: Lovastatina
Descriptor in French: Lovastatine
Entry term(s): 1 alpha-Isomer Lovastatin
6 Methylcompactin
6-Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha Isomer
Lovastatin, 1 alpha-Isomer
MK 803
MK-803
MK803
Mevacor
Mevinolin
Monacolin K
alpha-Isomer Lovastatin, 1
Tree number(s): D02.455.426.559.847.638.400
D04.615.638.400
Scope note: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
DeCS UI: 22932
Descriptor UI: D008148
Date Established: 1988/01/01
Date of Entry: 1987/05/04
Revision Date: 2015/06/23
Lovastatin - Preferred
Concept UI M0012707
Scope note A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Preferred term Lovastatin
Entry term(s) 6 Methylcompactin
6-Methylcompactin
Mevinolin
Monacolin K
MK-803 - Narrower
Concept UI M0354780
Preferred term MK-803
Entry term(s) MK 803
MK803
Mevacor - Narrower
Concept UI M0354781
Preferred term Mevacor
Lovastatin, (1 alpha(S*))-Isomer - Narrower
Concept UI M0330091
Preferred term Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha-Isomer - Narrower
Concept UI M0330090
Preferred term Lovastatin, 1 alpha-Isomer
Entry term(s) 1 alpha-Isomer Lovastatin
Lovastatin, 1 alpha Isomer
alpha-Isomer Lovastatin, 1



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