| Descriptor English: | Lovastatin | ||||||
| Descriptor Spanish: |
Lovastatina
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| Descriptor Portuguese: | Lovastatina | ||||||
| Descriptor French: | Lovastatine | ||||||
| Entry term(s): |
1 alpha-Isomer Lovastatin 6 Methylcompactin 6-Methylcompactin Lovastatin, (1 alpha(S*))-Isomer Lovastatin, 1 alpha Isomer Lovastatin, 1 alpha-Isomer MK 803 MK-803 MK803 Mevacor Mevinolin Monacolin K alpha-Isomer Lovastatin, 1 |
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| Tree number(s): |
D02.455.426.559.847.638.400 D04.615.638.400 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D008148 | ||||||
| Scope note: | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Anticholesteremic Agents Hydroxymethylglutaryl-CoA Reductase Inhibitors |
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| Registry Number: | 9LHU78OQFD | ||||||
| CAS Type 1 Name: | Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- | ||||||
| Previous Indexing: |
Anticholesteremic Agents (1966-1987) Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987) Naphthalenes (1966-1987) |
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| Public MeSH Note: | 88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980 |
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| History Note: | 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98 |
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| DeCS ID: | 22932 | ||||||
| Unique ID: | D008148 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1988/01/01 | ||||||
| Date of Entry: | 1987/05/04 | ||||||
| Revision Date: | 2015/06/23 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds
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Lovastatin
- Preferred
MK-803
- Narrower
Mevacor
- Narrower
Lovastatin, (1 alpha(S*))-Isomer
- Narrower
Lovastatin, 1 alpha-Isomer
- Narrower
| Concept UI |
M0012707 |
| Scope note | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
| Preferred term | Lovastatin |
| Entry term(s) |
6 Methylcompactin 6-Methylcompactin Mevinolin Monacolin K |
| Concept UI |
M0354780 |
| Preferred term | MK-803 |
| Entry term(s) |
MK 803 MK803 |
| Concept UI |
M0354781 |
| Preferred term | Mevacor |
| Concept UI |
M0330091 |
| Preferred term | Lovastatin, (1 alpha(S*))-Isomer |
| Concept UI |
M0330090 |
| Preferred term | Lovastatin, 1 alpha-Isomer |
| Entry term(s) |
1 alpha-Isomer Lovastatin Lovastatin, 1 alpha Isomer alpha-Isomer Lovastatin, 1 |
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