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Descriptor English: Lovastatin
Descriptor Spanish: Lovastatina
Descriptor lovastatina
Entry term(s) mevinolina
Scope note: Metabolito fúngico aislado de cultivos de Aspergillus terreus. El compuesto es un potente agente anticolesterémico. Inhibe la 3-hidroxi-3-metilglutaril coenzima A reductasa (HIDROXIMETILGLUTARIL COA REDUCTASAS), que es la enzima limitante de la velocidad en la biosíntesis del colesterol. Estimula también la producción de receptores de las lipoproteínas de baja densidad del hígado.
Descriptor Portuguese: Lovastatina
Descriptor French: Lovastatine
Entry term(s): 1 alpha-Isomer Lovastatin
6 Methylcompactin
6-Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha Isomer
Lovastatin, 1 alpha-Isomer
MK 803
MK-803
MK803
Mevacor
Mevinolin
Monacolin K
alpha-Isomer Lovastatin, 1
Tree number(s): D02.455.426.559.847.638.400
D04.615.638.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008148
Scope note: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticholesteremic Agents
Anticolesterolemiantes
Anticolesterolemiantes
Anticholestérolémiants
anticolesterolemiantes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inhibidores de Hidroximetilglutaril-CoA Reductasas
Inibidores de Hidroximetilglutaril-CoA Redutases
Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
inhibidores de las hidroximetilglutaril-CoA reductasas
Registry Number: 9LHU78OQFD
CAS Type 1 Name: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Previous Indexing: Anticholesteremic Agents (1966-1987)
Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987)
Naphthalenes (1966-1987)
Public MeSH Note: 88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980
History Note: 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
DeCS ID: 22932
Unique ID: D008148
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/05/04
Revision Date: 2015/06/23
Lovastatin - Preferred
Concept UI M0012707
Scope note A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Preferred term Lovastatin
Entry term(s) 6 Methylcompactin
6-Methylcompactin
Mevinolin
Monacolin K
MK-803 - Narrower
Concept UI M0354780
Preferred term MK-803
Entry term(s) MK 803
MK803
Mevacor - Narrower
Concept UI M0354781
Preferred term Mevacor
Lovastatin, (1 alpha(S*))-Isomer - Narrower
Concept UI M0330091
Preferred term Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha-Isomer - Narrower
Concept UI M0330090
Preferred term Lovastatin, 1 alpha-Isomer
Entry term(s) 1 alpha-Isomer Lovastatin
Lovastatin, 1 alpha Isomer
alpha-Isomer Lovastatin, 1



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