Descriptor in English: | Lovastatin |
Descriptor in Spanish: | Lovastatina |
Descriptor in Portuguese: | Lovastatina |
Descriptor in French: | Lovastatine |
Entry term(s): |
1 alpha-Isomer Lovastatin 6 Methylcompactin 6-Methylcompactin Lovastatin, (1 alpha(S*))-Isomer Lovastatin, 1 alpha Isomer Lovastatin, 1 alpha-Isomer MK 803 MK-803 MK803 Mevacor Mevinolin Monacolin K alpha-Isomer Lovastatin, 1 |
Tree number(s): |
D02.455.426.559.847.638.400 D04.615.638.400 |
Scope note: | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
History Note: | 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98 |
DeCS UI: | 22932 |
Descriptor UI: | D008148 |
Date Established: | 1988/01/01 |
Date of Entry: | 1987/05/04 |
Revision Date: | 2015/06/23 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Polycyclic Compounds [D04]Polycyclic Compounds
|
Lovastatin
- Preferred
MK-803
- Narrower
Mevacor
- Narrower
Lovastatin, (1 alpha(S*))-Isomer
- Narrower
Lovastatin, 1 alpha-Isomer
- Narrower
Concept UI |
M0012707 |
Scope note | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
Preferred term | Lovastatin |
Entry term(s) |
6 Methylcompactin 6-Methylcompactin Mevinolin Monacolin K |
Concept UI |
M0354780 |
Preferred term | MK-803 |
Entry term(s) |
MK 803 MK803 |
Concept UI |
M0354781 |
Preferred term | Mevacor |
Concept UI |
M0330091 |
Preferred term | Lovastatin, (1 alpha(S*))-Isomer |
Concept UI |
M0330090 |
Preferred term | Lovastatin, 1 alpha-Isomer |
Entry term(s) |
1 alpha-Isomer Lovastatin Lovastatin, 1 alpha Isomer alpha-Isomer Lovastatin, 1 |
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