Descriptor English: Neuropil Threads
Descriptor Spanish: Hilos del Neurópilo
Descriptor Portuguese: Filamentos do Neurópilo
Descriptor French: Fibres tortueuses
Tree number(s): A08.637.500.550
RDF Unique Identifier:
Scope note: Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Annotation: do not confuse with NEUROPIL, a "felt" of interwoven neuronal components & neuroglia
Allowable Qualifiers: CH composition chimique
CL classification
DE effets des médicaments et des substances chimiques
EN enzymologie
GE génétique
IM immunologie
ME métabolisme
MI microbiologie
PA anatomopathologie
PH physiologie
PS parasitologie
RE effets des radiations
TR transplantation
UL ultrastructure
VI virologie
DeCS ID: 33622
Unique ID: D019600
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2012/09/27
Fibres tortueuses - Preferred
Concept UI M0029099
Preferred term Fibres tortueuses

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