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Descriptor English: Neuropil Threads
Descriptor Spanish: Hilos del Neurópilo
Descriptor hilos del neurópilo
Entry term(s) filamentos del neurópilo
hebras del neurópilo
Scope note: Estructuras anormales localizadas fundamentalmente en las dendritas distales que, junto con los OVILLOS NEUROFIBRILARES y las PLACAS SENILES, constituyen las tres señales morfológicas de la ENFERMEDAD DE ALZHEIMER. Los hilos del neurópilo están formados por pares de filamentos helicoidales o rectos, que están compuestos por proteínas tau asociadas a microtúbulos anormalmente fosforiladas. Se ha sugerido que éstos hilos hallados en el neurópilo tienen un importante papel en los trastornos cognitivos que se observan en la enfermedad de Alzheimer.
Descriptor Portuguese: Filamentos do Neurópilo
Descriptor French: Fibres tortueuses
Entry term(s): Neuropil Thread
Tree number(s): A08.637.500.550
A08.675.703.550
A11.284.430.214.190.750.602.620
A11.650.500.550
A11.671.685.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019600
Scope note: Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Annotation: do not confuse with NEUROPIL, a "felt" of interwoven neuronal components & neuroglia
Allowable Qualifiers: CH chemistry
CL classification
DE drug effects
EN enzymology
GE genetics
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Public MeSH Note: 98
History Note: 98
DeCS ID: 33622
Unique ID: D019600
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2012/09/27
Neuropil Threads - Preferred
Concept UI M0029099
Scope note Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.
Preferred term Neuropil Threads
Entry term(s) Neuropil Thread



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