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Descriptor English: Sirolimus
Descriptor Spanish: Sirolimus
Descriptor sirólimus
Entry term(s) rapamicina
sirolimus
Scope note: Compuesto macrólido obtenido de Streptomyces hygroscopicus que actúa bloqueando selectivamente la activación transcripcional de citocinas, inhibiendo por consiguiente la producción de citocinas. Es bioactivo sólamente cuando se encuentra unido a las INMUNOFILINAS. El sirolimús es un potente inmunosupresor y posee propiedades antifúngicas y antineoplásicas.
Descriptor Portuguese: Sirolimo
Descriptor French: Sirolimus
Entry term(s): AY 22 989
AY 22-989
AY 22989
I 2190A
I-2190A
I2190A
Rapamune
Rapamycin
Tree number(s): D02.540.505.760
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020123
Scope note: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Antibiotics, Antineoplastic
Antifungal Agents
Immunosuppressive Agents
Registry Number: W36ZG6FT64
Previous Indexing: Polyenes (1976-1998)
Public MeSH Note: 99; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-98
History Note: 99; use SIROLIMUS (NM) 1980-97
DeCS ID: 33809
Unique ID: D020123
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/11
Revision Date: 2016/07/01
Sirolimus - Preferred
Concept UI M0029863
Scope note A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Preferred term Sirolimus
Entry term(s) Rapamycin
I-2190A - Narrower
Concept UI M0514457
Preferred term I-2190A
Entry term(s) I 2190A
I2190A
AY 22-989 - Narrower
Concept UI M0352047
Preferred term AY 22-989
Entry term(s) AY 22 989
AY 22989
Rapamune - Narrower
Concept UI M0352046
Preferred term Rapamune



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