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Descriptor English: MPTP Poisoning
Descriptor Spanish: Intoxicación por MPTP
Descriptor intoxicación por MPTP
Entry term(s) envenenamiento por MPTP
síndrome de neurotoxicidad por MPTP
Scope note: Afección causada por la neurotoxina 1-METIL-4-FENIL-1,2,3,6-TETRAHIDROPIRIDINA (MPTP) que ocasiona destrucción selectiva de las neuronas nigroestriadas dopaminérgicas. Las características clínicas incluyen signos irreversibles de parkinsonismo con rigidez y bradicinesia (ENFERMEDAD DE PARKINSON SECUNDARIA). La toxicidad del MPTP se utiliza también como modelo animal para el estudio de la ENFERMEDAD DE PARKINSON. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Descriptor Portuguese: Intoxicação por MPTP
Descriptor French: Intoxication au MPTP
Entry term(s): MPTP Induced Degeneration of the Striatum
MPTP Induced Parkinsonism
MPTP Neurotoxicity Syndrome
MPTP Neurotoxicity Syndromes
MPTP-Induced Degeneration of the Striatum
MPTP-Induced Parkinsonism
Neurotoxicity Syndrome, MPTP
Neurotoxicity Syndromes, MPTP
Parkinsonism, MPTP-Induced
Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Poisoning, MPTP
Tree number(s): C10.228.140.079.862.800.300
C10.228.662.600.700.250
C10.720.606
C25.723.705.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020267
Scope note: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Annotation: not for animal models of Parkinson disease induced by MPTP: index MPTP-INDUCED EXPERIMENTAL PARKINSONISM
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/poisoning (1990-1999)
Parkinson Disease, Secondary (1983-1999)
Public MeSH Note: 2000
History Note: 2000
Entry Version: MPTP POIS
Related: 1-Methyl-4-phenylpyridinium MeSH
DeCS ID: 34225
Unique ID: D020267
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2010/06/25
MPTP Poisoning - Preferred
Concept UI M0328147
Scope note A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Preferred term MPTP Poisoning
Entry term(s) MPTP Induced Parkinsonism
MPTP Neurotoxicity Syndrome
MPTP Neurotoxicity Syndromes
MPTP-Induced Parkinsonism
Neurotoxicity Syndrome, MPTP
Neurotoxicity Syndromes, MPTP
Parkinsonism, MPTP-Induced
Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Poisoning, MPTP
MPTP-Induced Degeneration of the Striatum - Narrower
Concept UI M0332996
Preferred term MPTP-Induced Degeneration of the Striatum
Entry term(s) MPTP Induced Degeneration of the Striatum



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