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Descriptor English: Neuroleptic Malignant Syndrome
Descriptor Spanish: Síndrome Neuroléptico Maligno
Descriptor síndrome neuroléptico maligno
Entry term(s) síndrome maligno neuroléptico de inducción neuroléptica
síndrome neuroléptico maligno de inducción neuroléptica
Scope note: Síndrome potencialmente fatal asociado principalmente con el empleo de agentes neurolépticos (ver AGENTES ANTIPSICÓTICOS) que a su vez se asocian con bloqueo de los receptores dopaminérgicos (ver RECEPTORES DE DOPAMINA) en los GANGLIOS BASALES e HIPOTÁLAMO y la disregulación simpática. Las características clínicas incluyen RIGIDEZ MUSCULAR difusa, TEMBLOR, FIEBRE alta, diaforesis, presión sanguínea lábi, disfunción cognoscitiva y trastornos autonómicos. También puede presentarse elevación de los niveles séricos de CPK y leucocitosis. (Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Descriptor Portuguese: Síndrome Maligna Neuroléptica
Descriptor French: Syndrome malin des neuroleptiques
Entry term(s): NMS (Neuroleptic Malignant Syndrome)
NMSs (Neuroleptic Malignant Syndrome)
Neuroleptic Induced Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome, Neuroleptic Induced
Neuroleptic Malignant Syndromes
Neuroleptic-Induced Neuroleptic Malignant Syndrome
Neuroleptic-Malignant Syndrome, Neuroleptic Induced
Syndrome, Neuroleptic Malignant
Syndromes, Neuroleptic Malignant
Tree number(s): C10.228.140.079.737
C10.720.737
C25.723.705.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009459
Scope note: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Annotation: caused by tranquilizing agents so do not use /chem ind
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Basal Ganglia Diseases (1979-1984)
Fever (1966-1984)
Malignant Hyperthermia (1973-1984)
Muscle Rigidity (1972-1984)
Tranquilizing Agents, Major (1975-1984)
Public MeSH Note: 1986; see BASAL GANGLIA DISEASES 1985
History Note: 1986(1985)
DeCS ID: 9650
Unique ID: D009459
NLM Classification: WL 307
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1984/06/05
Revision Date: 2010/06/25
Neuroleptic Malignant Syndrome - Preferred
Concept UI M0014713
Scope note A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Preferred term Neuroleptic Malignant Syndrome
Entry term(s) NMS (Neuroleptic Malignant Syndrome)
NMSs (Neuroleptic Malignant Syndrome)
Neuroleptic Malignant Syndromes
Syndrome, Neuroleptic Malignant
Syndromes, Neuroleptic Malignant
Neuroleptic-Induced Neuroleptic Malignant Syndrome - Narrower
Concept UI M0332878
Preferred term Neuroleptic-Induced Neuroleptic Malignant Syndrome
Entry term(s) Neuroleptic Induced Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome, Neuroleptic Induced
Neuroleptic-Malignant Syndrome, Neuroleptic Induced



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