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Descriptor English: RGS Proteins
Descriptor Spanish: Proteínas RGS
Descriptor proteínas RGS
Entry term(s) proteínas de señalización de los reguladores de proteína G
Scope note: Gran familia de proteínas evolucionariamente conservadas que funcionan como reguladores negativos de las PROTEÍNAS DE UNIÓN AL GTP HETEROTRIMÉRICAS. las PROTEÍNAS RGS actúan aumentando la actividad GTPasa de la subunidad G alfa de una proteína hetrotrimérica fijadora de GTP, lo que hace que revierta a su forma inactiva (unida a GDP).
Descriptor Portuguese: Proteínas RGS
Descriptor French: Protéines RGS
Entry term(s): RGS Protein (G-Protein Signaling)
Regulators of G Protein Signaling Proteins
Regulators of G-Protein Signaling Proteins
Tree number(s): D12.644.360.325.150.750
D12.776.476.325.150.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020710
Scope note: A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
Annotation: do not confuse with GTP-BINDING PROTEIN REGULATORS; not the same as RGS tripeptide
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: GTP Phosphohydrolase Activators
Previous Indexing: Proteins (1989-1999)
Public MeSH Note: 2000; RGS PROTEIN (G-PROTEIN SIGNALING) was indexed under PROTEINS 1997-1999
History Note: 2000; for RGS PROTEIN (G-PROTEIN SIGNALING) use GTPASE-ACTIVATING PROTEINS (NM) 1997-1999
DeCS ID: 34487
Unique ID: D020710
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2015/11/24
RGS Proteins - Preferred
Concept UI M0328278
Scope note A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
Preferred term RGS Proteins
Entry term(s) RGS Protein (G-Protein Signaling)
Regulators of G Protein Signaling Proteins
Regulators of G-Protein Signaling Proteins



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