| Descriptor English: | Eukaryotic Initiation Factor-5 | ||||||
| Descriptor Spanish: |
Factor 5 Eucariótico de Iniciación
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| Descriptor Portuguese: | Fator de Iniciação 5 em Eucariotos | ||||||
| Descriptor French: | Facteur-5 d'initiation eucaryote | ||||||
| Entry term(s): |
EIF-5 Eukaryotic Initiation Factor 5 Eukaryotic Peptide Initiation Factor 5 Eukaryotic Peptide Initiation Factor-5 Initiation Factor-5, Eukaryotic Peptide Initiation Factor EIF 5 Peptide Initiation Factor EIF-5 |
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| Tree number(s): |
D12.644.360.325.150.300 D12.776.476.325.150.300 D12.776.835.725.868.750 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D040061 | ||||||
| Scope note: | A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
GTP Phosphohydrolase Activators |
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| Previous Indexing: |
Peptide Initiation Factors (1982-2002) |
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| Public MeSH Note: | 2003; EIF-5 (now EUKARYOTIC INITIATION FACTOR-5) was indexed under PEPTIDE INITIATION FACTORS 1982-2002 |
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| History Note: | 2003; use EUKARYOTIC INITIATION FACTOR-5 (NM) 1982-2002 |
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| DeCS ID: | 37453 | ||||||
| Unique ID: | D040061 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Eukaryotic Initiation Factor-5
- Preferred
| Concept UI |
M0110035 |
| Scope note | A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex |
| Preferred term | Eukaryotic Initiation Factor-5 |
| Entry term(s) |
EIF-5 Eukaryotic Initiation Factor 5 Eukaryotic Peptide Initiation Factor 5 Eukaryotic Peptide Initiation Factor-5 Initiation Factor-5, Eukaryotic Peptide Initiation Factor EIF 5 Peptide Initiation Factor EIF-5 |
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