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Descriptor English: alpha Karyopherins
Descriptor Spanish: alfa Carioferinas
Descriptor alfa carioferinas
Scope note: Moléculas de transporte nucleocitoplasmáticas que se unen a las SEÑALES DE LOCALIZACION NUCLEAR de las moléculas del citoplasma que deben ser importadas al NÚCLEO CELULAR. Una vez acopladas a su transporte, se unen a las BETA CARIOFERINAS y son trasportadas a través del COMPLEJO DE POROS NUCLEAR. Ya en el interior del NUCLEO CELULAR, las alfa carioferinas se disocian de las beta carioferinas y su transporte. Seguidamente forman un complejo con la PROTEÍNA DE SUSCEPTIBILIDAD DE APOPTOSIS CELULAR y la PROTEÍNA DE UNIÓN GTP RAN, que son exportadas al CITOPLASMA.
Descriptor Portuguese: alfa Carioferinas
Descriptor French: Cariophérines alpha
Entry term(s): Importin-alpha
Karyopherin alpha
Karyopherins, alpha
NLS Receptor
NLS-Binding Protein
NLSBP
Nuclear Localization Sequence Receptor
Nuclear Localization Signal-Binding Protein
receptor, NLS
Tree number(s): D12.776.157.530.750.500.100
D12.776.543.585.750.500.100
D12.776.660.502.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D028901
Scope note: Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nuclear Proteins (1994-2001)
Public MeSH Note: 2002; KARYOPHERIN ALPHA (now ALPHA KARYOPHERINS) was indexed under NUCLEAR PROTEINS 1994-2001; IMPORTIN-ALPHA was indexed under NUCLEAR PROTEINS 1995-2001; NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN were indexed under NUCLEAR PROTEINS & PHOSPHOPROTEINS 1992-2001
History Note: 2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001
Related: Nuclear Localization Signals MeSH
DeCS ID: 36192
Unique ID: D028901
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2005/07/12
alpha Karyopherins - Preferred
Concept UI M0240469
Scope note Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Preferred term alpha Karyopherins
Entry term(s) Importin-alpha
Karyopherin alpha
Karyopherins, alpha
NLS Receptor
NLS-Binding Protein
NLSBP
Nuclear Localization Sequence Receptor
Nuclear Localization Signal-Binding Protein
receptor, NLS



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