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Descriptor English: beta Karyopherins
Descriptor Spanish: beta Carioferinas
Descriptor beta carioferinas
Entry term(s) carioferina beta
Scope note: Moléculas de transporte nucleocitoplasmático que se unen a las ALFA CARIOFERINAS en el CITOSOL y están involucradas en el transporte de moléculas a través del COMPLEJO DE PORO NUCLEAR. Una vez dentro del NÚCLEO CELULAR, las beta carioferinas interactúan con las PROTEÍNAS DE UNÓN GTP RAN y se separan de las alfa carioferinas. Las beta carioferinas se unen a la PROTEÍNA DE UNIÓN GTP RAN para ser nuevamente transportadas al citoplasma, donde la hidrólisis del GTP de la PROTEÍNA DE UNIÓN GTP RAN hace que se liberen las beta carioferinas.
Descriptor Portuguese: beta Carioferinas
Descriptor French: Caryophérines bêta
Entry term(s): Importin beta
Importin-beta
Importins, beta
Kap95 protein
Karyopherin beta
Karyopherin beta Subunit
Karyopherin-beta
Karyopherin-beta Subunit
Karyopherins, beta
beta Importins
nuclear protein, p92
p92 nuclear protein
Tree number(s): D12.776.157.530.750.500.249
D12.776.543.585.750.500.249
D12.776.660.502.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D028961
Scope note: Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nuclear Proteins (1995-2001)
Public MeSH Note: 2002; KARYOPHERIN BETA & IMPORTIN-BETA were indexed under NUCLEAR PROTEINS 1995-2001
History Note: 2002; use BETA KARYOPHERINS (NM) 1995-2001; for IMPORTIN-BETA use KARYOPHERINS (NM) 1995-2001
DeCS ID: 36193
Unique ID: D028961
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2005/06/30
beta Karyopherins - Preferred
Concept UI M0249033
Scope note Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Preferred term beta Karyopherins
Entry term(s) Importin beta
Importin-beta
Importins, beta
Kap95 protein
Karyopherin beta
Karyopherin beta Subunit
Karyopherin-beta
Karyopherin-beta Subunit
Karyopherins, beta
beta Importins
nuclear protein, p92
p92 nuclear protein



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